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MRS2279 diammonium - ≥98% , CAS No.2387505-47-5
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a K i value of 2.5 nM and an IC 50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pK b value of 8.05
In Vitro
MRS2279 diammonium antagonizes 2-MeSADP-stimulated inositol phosphate formation in turkey erythrocyte membranes with a pK b value of 7.75. MRS2279 diammonium shows high affinity competitive antagonism to human P2Y1 receptor with a pK b value of 8.10 in 1321N1 human astrocytoma cells. MRS2279 diammonium shows specific effect for the P2Y1 receptor, but shows no effect on activation of the human P2Y2, P2Y4, P2Y6, or P2Y11 receptors by their cognate agonists. MRS2279 diammonium shows no ability to block the capacity of ADP to act through the Gi/adenylyl cyclase linked P2Y receptor of platelets to inhibit cyclic AMP accumulation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MRS2279 diammonium (2 μL, 1 nM; intracerebroventricular injection; 30 min prior to mechanical ventilation) reduces mouse brain injury induced by mechanical ventilation in high-pressure ventilation mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:P2Y1 Receptor 51.6 nM (IC 50 )
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a K i value of 2.5 nM and an IC 50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pK b value of 8.05.
Storage
Store at -20°C, Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Purity
≥98%
Names and Identifiers
| Molecular Weight | 503.77 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
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