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· · COA & SDS available for every product · Same-day shipping on in-stock items Pexacerfont - Moligand™, ≥98%(HPLC) , Corticotropin releasing factor receptor 1 antagonist, CAS No.459856-18-9, Corticotropin releasing factor receptor 1 antagonist
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC) Synonyms
D70085 | D10022 | LF1VBG4ZUK | Pexacerfont [USAN:INN] | ZB1563 | AKOS004115453 | BMS 562086 | EX-A3079 | AKOS040742389 | CRF1 ANTAGONIST | PEXACERFONT | PEXACERFONT [INN] | 8-(6-Methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
D70085 | D10022 | LF1VBG4ZUK | Pexacerfont [USAN:INN] | ZB1563 | AKOS004115453 | BMS 562086 | EX-A3079 | AKOS040742389 | CRF1 ANTAGONIST | PEXACERFONT | PEXACERFONT [INN] | 8-(6-Methoxy-2-methylpyridin-3-yl)-2, 7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent and selective corticotropin-releasing factor 1 receptor (CRF1) antagonist (IC50= 6.1 nM). Displays >150 fold selectivity for CRF1over CRF2b. Inhibits CRF-mediated adrenocorticotropic hormone (ACTH) release from pituitary cell culture (IC50= 129 nM)
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Corticotropin releasing factor receptor 1 antagonist
Product Properties Names and Identifiers Canonical Smiles CCC(C)NC1=NC(=NC2=C(C(=NN21)C)C3=C(N=C(C=C3)OC)C)C IUPAC Name N-[(2R)-butan-2-yl]-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine InChIKey LBWQSAZEYIZZCE-SNVBAGLBSA-N INCHI 1S/C18H24N6O/c1-7-10(2)19-18-22-13(5)21-17-16(12(4)23-24(17)18)14-8-9-15(25-6)20-11(14)3/h8-10H,7H2,1-6H3,(H,19,21,22)/t10-/m1/s1 Isomeric SMILES CC[C@@H](C)NC1=NC(=NC2=C(C(=NN21)C)C3=C(N=C(C=C3)OC)C)C PubChem CID 9884366 Molecular Weight 340.43
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Pyridines and derivatives Subclass Pyrazolylpyridines Intermediate Tree Nodes Not available Direct Parent Pyrazolylpyridines Alternative Parents Pyrazolotriazines Pyrazolo[1,5-a][1,3,5]triazines N-aliphatic s-triazines Methylpyridines Alkyl aryl ethers 1,3,5-triazines Pyrazoles Heteroaromatic compounds Azacyclic compounds Hydrocarbon derivatives Amines Molecular Framework Aromatic heteropolycyclic compounds Substituents 3-pyrazolylpyridine - Pyrazolo[1,5-a][1,3,5]triazine - Pyrazolotriazine - Alkyl aryl ether - Amino-1,3,5-triazine - Methylpyridine - Aminotriazine - N-aliphatic s-triazine - 1,3,5-triazine - Triazine - Azole - Pyrazole - Heteroaromatic compound - Ether - Azacycle - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Amine - Organic oxygen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as pyrazolylpyridines. These are compounds containing a pyrazolylpyridine skeleton, which consists of a pyrazole linked (not fused) to a pyridine by a bond. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 34.04, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 34.04, Max Conc. mM: 100 Molecular Weight 340.400 g/mol XLogP3 3.800 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 5 Exact Mass 340.201 Da Monoisotopic Mass 340.201 Da Topological Polar Surface Area 77.200 Ų Heavy Atom Count 25 Formal Charge 0 Complexity 438.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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