Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

PS315, a derivative of PS48 , is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKC ζ ( IC 50 =10 μM) and PKC η ( IC 50 =30 μM). PS315 has anti-cancer activity.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Canonical Smiles: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=CC(=O)O)CCC3=CC=C(C=C3)Cl
• IUPAC Name: 5-(4-chlorophenyl)-3-(4-phenylphenyl)pent-2-enoic acid
• InChIKey: KXEKGLNMBLODQT-UHFFFAOYSA-N
• INCHI: 1S/C23H19ClO2/c24-22-14-7-17(8-15-22)6-9-21(16-23(25)26)20-12-10-19(11-13-20)18-4-2-1-3-5-18/h1-5,7-8,10-16H,6,9H2,(H,25,26)
• Isomeric SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=CC(=O)O)CCC3=CC=C(C=C3)Cl
• PubChem CID: 66759644