GRADE & PURITYAnimal Free?Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material.Carrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Recombinant?Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin.Low Endotoxin?Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere.≥95%(SDS-PAGE)
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Recombinant Human Type XVII Collagen is 100% human-homologous, featuring high biocompatibility and excellent safety (cell viability reaches 99.74% at a concentration of 10 mg/mL).
Specifically expressed in the basement membrane of the hair follicle bulge region, this collagen serves as the core structural and signaling hub that maintains hair follicle stem cell function. It exerts dual effects of structural support and signal transduction: it not only stabilizes the adhesion of hair follicle stem cells and reconstructs the scaffold of the hair follicle microenvironment, but also activates the Wnt/β-catenin pathway (with WNT10B expression increased by 278.7%) and upregulates VEGF (increased to 92.4% of the model group). This awakens dormant hair follicle stem cells, promotes angiogenesis, remodels the hair follicle growth cycle, fundamentally improves hair loss, and achieves hair follicle regeneration and repair.
In terms of applications, it can be used to develop products such as daily care hair growth serums/gels, active coating solutions for microneedle delivery, and post-hair transplant repair kits, suitable for scenarios including home care for mild to moderate hair loss, combined aesthetic medical treatment, and post-transplant hair care.
Specifications
Product Name
Recombinant Human Type XVII Collagen, CAS No.9007-34-5
May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target
2.Junjie Li, Yixu Wang, Jiawei Li, Sihan Xu, Shou Wang, Wenjuan Liu, Li Fu, Min Jiang, Gang Bai. (2024) Phillyrin and its metabolites treat pulmonary embolism by targeting PLCβ3 to inhibit platelet activation. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:38866117][10.1016/j.jep.2024.118457]
3.Yufeng Dai, Jinxiang Chen, Jialong Fang, Shuxiao Liang, Hao Zhang, Haitao Li, Wei Chen. (2024) Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A2 receptor. BIOCHEMICAL PHARMACOLOGY, [PMID:39236933][10.1016/j.bcp.2024.116518]
4.Yu Han, Xiufeng Jia, Yinwei Yang, Pei Guo, Chao Li, Yunze Zhang, Li Yin, Bo Jia, Haitao Wang. (2025) Study of bioactive 3D-printed scaffolds incorporating zinc-based MOF for bone defect repair and anti-inflammatory applications. Materials Today Bio, [PMID:40510838][10.1016/j.mtbio.2025.101884]
5.Yunxia Du, Di Xiao, Changle Ren, Zhenlan Li, Xiaofeng Wang, Yantao Zhao, Yongmei Jiang. (2026) pH-responsive polydopamine-shelled 3D-printed chitosan/collagen hydrogel integrating exosomes and an enzyme/peptide cascade for diabetic wound healing. Biomaterials Science, [PMID:41685930][10.1039/D5BM01823D]
6.Zhonghao Li, Zhihan Cai, Tao Zhu, Chaoyang Gong. (2026) Visualization of Protein Network Mechanical Heterogeneity Using Ultrasound-Coupled Microcavity Lasers. Laser & Photonics Reviews, [PMID:][10.1002/lpor.202502742]
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