Rifabutin - Moligand™, ≥98% , Bacterial DNA-directed RNA polymerase inhibitor, CAS No.72559-06-9, Bacterial DNA-directed RNA polymerase inhibitor

CAS: 72559-06-9 Cat. No.: R129919 Molecular Weight: 847 EC Number: 615-780-3 PubChem CID: 135398743

GRADE & PURITY Moligand™, ≥98%

Synonyms

LM-427 | HSDB 3577 | Mycobutin | Rifamycin XIV, 1',4-didehydro-1-deoxy-1,4-dihydro-5'-(2-methylpropyl)-1-oxo- | (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6-16,18,20-Tetrahydroxy-1'-isobutyl-14-methoxy-7,9,15,17,19,21,25-heptamethylspiro(9,4-(epoxyp

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Rifabutin is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis.
A semisynthetic antibacterial derivative of Rifamycin S.

Specifications

Synonyms

LM-427 | HSDB 3577 | Mycobutin | Rifamycin XIV, 1', 4-didehydro-1-deoxy-1, 4-dihydro-5'-(2-methylpropyl)-1-oxo- | (9S, 12E, 14S, 15R, 16S, 17R, 18R, 19R, 20S, 21S, 22E, 24Z)-6-16, 18, 20-Tetrahydroxy-1'-isobutyl-14-methoxy-7, 9, 15, 17, 19, 21, 25-heptamethylspiro(9, 4-(epoxyp

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Rifabutin is a semisynthetic derivative of Rifamycin S. It acts as an antibacterial (tuberculostatic) that inhibits nucleic acid synthesis.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Bacterial DNA-directed RNA polymerase inhibitor

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504773247
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773247
• Isomeric SMILES: C[C@H]1/C=C/C=C(\C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)O[C@@](C6=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)O)/C
• WGK Germany: 3
• RTECS: VJ6700000
• PubChem CID: 135398743
• Molecular Weight: 847

Chemical and Physical Properties

• Solubility: DMSO 60 mg/mL Water <1 mg/mL Ethanol 40 mg/mL
• Sensitivity: light sensitive；Heat sensitive
• Melt Point(°C): 156 °C
• Molecular Weight: 847.000 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 5
• Exact Mass: 846.442 Da
• Monoisotopic Mass: 846.442 Da
• Topological Polar Surface Area: 209.000 Ų
• Heavy Atom Count: 61
• Formal Charge: 0
• Complexity: 2110.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 3
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 3
• Covalently-Bonded Unit Count: 1