TRPV1 antagonist 3 - ≥99% , CAS No.T659415

CAS: T659415 Cat. No.: T659415 Molecular Weight: 391.53

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC 50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant.

Appearance:Solid

IC50& Target:hTRPV1 2.66 nM (IC 50 ) TRPM8 7.45 μM (IC 50 )

In Vitro:TRPV1 antagonist 3 (Compound 7q) is highly selective for the TRPV1 receptor relative to other TRP channels. TRPV1 antagonist 3 shows acceptable aqueous solubility (solubility at pH 7.4 = 26 μg/mL). MCE has not independently confirmed the accurac

In Vivo:TRPV1 antagonist 3 (Compound 7q) (0-30mg/kg; i.p.; 30 min) shows anti-nociceptive effect mainly mediated by blocking CAP-activated channel. TRPV1 antagonist 3 (0-100mg/kg; i.g.) had no obvious thermal effect in rats. TRPV1 antagonist 3 (10 mg/

Biological Activity:TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC 50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant.

Specifications

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC(C1=CC=CC(NC(N2CCC[C@H]2C3=NC=C(S3)C4=CC=CC=C4)=O)=C1)C
• Molecular Weight: 391.53

Chemical and Physical Properties

• Solubility: DMSO : ≥ 100 mg/mL (255.41 mM)