U-73343 - ≥98% , CAS No.142878-12-4

CAS: 142878-12-4 Cat. No.: U276451 Molecular Weight: 466.7 EC Number: 634-320-2 PubChem CID: 114825

GRADE & PURITY ≥98%

Synonyms

2,5-PYRROLIDINEDIONE, 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)- | 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-2,5-PYRROLIDINEDIONE | DTXSID2036740 | S2C4J8704C | SCHEMBL2678917 | 1-(6-((17BETA-3-METHOXYES

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Product description：

U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC。

Application：

U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells.

U-73343 has been used in measuring the fluorescence of intracellular Ca2+.

Specifications

Synonyms

2, 5-PYRROLIDINEDIONE, 1-(6-(((17.BETA.)-3-METHOXYESTRA-1, 3, 5(10)-TRIEN-17-YL)AMINO)HEXYL)- | 1-(6-(((17.BETA.)-3-METHOXYESTRA-1, 3, 5(10)-TRIEN-17-YL)AMINO)HEXYL)-2, 5-PYRROLIDINEDIONE | DTXSID2036740 | S2C4J8704C | SCHEMBL2678917 | 1-(6-((17BETA-3-METHOXYES

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Negative control for phospholipase C (PLC) inhibitor U73122 .

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504756725
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756725
• Canonical Smiles: CC12CCC3C(C1CCC2NCCCCCCN4C(=O)CCC4=O)CCC5=C3C=CC(=C5)OC
• IUPAC Name: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrolidine-2,5-dione
• InChIKey: CJHWFIUASFBCKN-ZRJUGLEFSA-N
• INCHI: 1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)CCC4=O)CCC5=C3C=CC(=C5)OC
• PubChem CID: 114825
• Molecular Weight: 466.7

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Steroids and steroid derivatives
      • Subclass Azasteroids and derivatives

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Steroids and steroid derivatives
• Subclass: Azasteroids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Azasteroids and derivatives
• Alternative Parents: Estrane steroids Phenanthrenes and derivatives Tetralins Anisoles Alkyl aryl ethers Aralkylamines Pyrrolidine-2-ones N-substituted carboxylic acid imides N-alkylpyrrolidines Dicarboximides Amino acids and derivatives Lactams Dialkylamines Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 20-azasteroid - Estrane-skeleton - Azasteroid - Phenanthrene - Tetralin - Anisole - Alkyl aryl ether - Aralkylamine - Carboxylic acid imide, n-substituted - Pyrrolidone - 2-pyrrolidone - N-alkylpyrrolidine - Benzenoid - Carboxylic acid imide - Dicarboximide - Pyrrolidine - Amino acid or derivatives - Lactam - Carboxylic acid derivative - Azacycle - Secondary aliphatic amine - Organoheterocyclic compound - Secondary amine - Ether - Amine - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxygen compound - Organopnictogen compound - Organic oxide - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as azasteroids and derivatives. These are steroid derivatives in which one carbon atom in the steroidal skeleton has been substituted with a nitrogen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ARSA Tbio Cerebroside-sulfatase (655 Activities)

Discover Target: ARSA

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MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

Discover Target: MTOR

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SH-SY5Y (11521 Activities)

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HEK293 (82097 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Saccharomyces cerevisiae (19171 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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hsp60 Chaperonin GroEL (Thermosome, HSP60 family) (16 Activities)

Discover Target: hsp60

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO (Slightly, Heated, Sonicated), Ethanol (Slightly, Heated), Methanol (Slightly)
• Melt Point(°C): 139- 141° C
• Molecular Weight: 466.700 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 466.32 Da
• Monoisotopic Mass: 466.32 Da
• Topological Polar Surface Area: 58.600 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 725.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1