Viramidine Hydrochloride - ≥98% , CAS No.40372-00-7

CAS: 40372-00-7 Cat. No.: V349004 Molecular Weight: 279.68

GRADE & PURITY ≥98%

Synonyms

Taribavirin (hydrochloride) | Taribavirin hydrochloride [USAN] | 1-(beta -D-ribofuranosyl)-1,2,4-triazole-3-carboxamidine hydrochloride | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboximidamide hydrochloride | TARI

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Viramidine Hydrochloride is a liver-targeting antiviral nucleoside analog. A 3-carboxamidine prodrug of Ribavirin.

Product description

Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and the development of hemolytic anemia.

Specifications

Synonyms

Taribavirin (hydrochloride) | Taribavirin hydrochloride [USAN] | 1-(beta -D-ribofuranosyl)-1, 2, 4-triazole-3-carboxamidine hydrochloride | 1-[(2R, 3R, 4S, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1, 2, 4-triazole-3-carboximidamide hydrochloride | TARI

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504758890
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504758890
• Canonical Smiles: C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=N)N.Cl
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboximidamide;hydrochloride
• InChIKey: PIGYMBULXKLTCJ-UHSSARMYSA-N
• INCHI: 1S/C8H13N5O4.ClH/c9-6(10)7-11-2-13(12-7)8-5(16)4(15)3(1-14)17-8;/h2-5,8,14-16H,1H2,(H3,9,10);1H/t3-,4-,5-,8-;/m1./s1
• Isomeric SMILES: C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=N)N.Cl
• Alternate CAS: 119567-79-2
• Molecular Weight: 279.68

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Class Triazole ribonucleosides and ribonucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Class: Triazole ribonucleosides and ribonucleotides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Triazole ribonucleosides and ribonucleotides
• Alternative Parents: Glycosylamines Pentoses Triazoles Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Oxacyclic compounds Carboximidamides Carboxamidines Azacyclic compounds Primary alcohols Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: N-ribosyl-1,2,4-triazole - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Monosaccharide - Azole - Tetrahydrofuran - Triazole - 1,2,4-triazole - Heteroaromatic compound - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Carboxylic acid amidine - Carboximidamide - Amidine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Primary alcohol - Hydrochloride - Organic nitrogen compound - Alcohol - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as triazole ribonucleosides and ribonucleotides. These are nucleoside derivatives containing a ribose (or deoxyribose) moiety which is N-glycosylated to a triazole. Nucleotides have a phosphate group linked to the C5 carbon of the ribose (or deoxyribose) moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Vaccinia virus (4609 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dengue virus type 4 (242 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Influenza A virus (11224 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Moisture sensitive
• Melt Point(°C): 167-172° C
• Molecular Weight: 279.680 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 279.073 Da
• Monoisotopic Mass: 279.073 Da
• Topological Polar Surface Area: 151.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 304.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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