Name: 2'-C-Methyladenosine - ≥99% , CAS No.15397-12-3
Brand: Aladdin Scientific
SKU: C650178
Availability: InStock

2'-C-Methyladenosine - ≥99% , CAS No.15397-12-3

CAS: 15397-12-3 Cat. No.: C650178 Molecular Weight: 281.27 PubChem CID: 500900

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2'-C-Methyladenosine - ≥99% CAS No(15397-12-3) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥99%

Synonyms

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication . 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC 50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis

In Vivo

2'-C-Methyladenosine has inhibitory potency for HCV replicon in HB110A cells with an IC 50 values of 0.3μM . 2'-C-Methyladenosine inhibits NS5B-catalyzed RNA synthesis with an IC 50 values of 1.9 μM . 2′-C-methyladenosine potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensisMCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 0.3μM (HCV replicon),1.9 μM (NS5B)

Specifications

Synonyms

(2R, 3R, 4R, 5R)-5-Hydroxymethyl-3-methyl-2-(6-methylamino-purin-9-yl)-tetrahydro-furan-3, 4-diol | beta-2''-Methyladenosine | Beta-2'-Methyladenosine | (3R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3, 4-diol | BDBM50144948 | (2R, 3R, 4R, 5R)-2-(6-

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Canonical Smiles	CC1(C(C(OC1N2C=NC3=C(N=CN=C32)N)CO)O)O
IUPAC Name	(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
InChIKey	PASOFFRBGIVJET-YRKGHMEHSA-N
INCHI	1S/C11H15N5O4/c1-11(19)7(18)5(2-17)20-10(11)16-4-15-6-8(12)13-3-14-9(6)16/h3-5,7,10,17-19H,2H2,1H3,(H2,12,13,14)/t5-,7-,10-,11-/m1/s1
Isomeric SMILES	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)O)O
Alternate CAS	15397-12-3
PubChem CID	500900
MeSH Entry Terms	2'-C-methyladenosine;2'C-methyladenosine;2'CMA cpd
Molecular Weight	281.27

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Nucleosides, nucleotides, and analogues
  - Class Purine nucleosides

Kingdom	Organic compounds
Superclass	Nucleosides, nucleotides, and analogues
Class	Purine nucleosides
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Purine nucleosides
Alternative Parents	Glycosylamines 6-aminopurines Pentoses Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Tetrahydrofurans Tertiary alcohols Heteroaromatic compounds Secondary alcohols Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Organopnictogen compounds Primary alcohols Primary amines
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Purine nucleoside - Glycosyl compound - N-glycosyl compound - 6-aminopurine - Pentose monosaccharide - Purine - Imidazopyrimidine - Aminopyrimidine - N-substituted imidazole - Monosaccharide - Pyrimidine - Imidolactam - Azole - Imidazole - Tertiary alcohol - Tetrahydrofuran - Heteroaromatic compound - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Primary amine - Amine - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Primary alcohol - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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ADORA2A Tclin Adenosine A2a receptor (16305 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Caco-2 (12174 Activities)

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HT-29 (80576 Activities)

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Huh-7 (12904 Activities)

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K562 (73714 Activities)

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MCF7 (126967 Activities)

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A549 (127892 Activities)

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HeLa (62764 Activities)

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ADORA1 Tclin Adenosine receptors; A1 & A3 (1051 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA3 Tchem Adenosine receptors; A2a & A3 (373 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

NS5B Hepatitis C virus NS5B RNA-dependent RNA polymerase (3026 Activities)

Discover Target: NS5B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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West Nile virus (623 Activities)

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Hepatitis C virus (23859 Activities)

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MDBK441 (32 Activities)

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Bovine viral diarrhea virus 1 (1277 Activities)

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dengue virus type 2 (2400 Activities)

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Adora1 Adenosine receptors; A1 & A2a (368 Activities)

Discover Target: Adora1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 31.25 mg/mL (111.10 mM; ultrasonic and warming and heat to 60°C)
Molecular Weight	281.270 g/mol
XLogP3	-1.300
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Exact Mass	281.112 Da
Monoisotopic Mass	281.112 Da
Topological Polar Surface Area	140.000 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	375.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

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Reconstitution Calculator

Reviews

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2'-C-Methyladenosine - ≥99% , CAS No.15397-12-3

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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