BTK inhibitor 10 - ≥99% , CAS No.2241732-30-7

CAS: 2241732-30-7 Cat. No.: B651233 Molecular Weight: 441.48

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment

In Vivo

BTK inhibitor 10 (oral gavage; 30 mg/kg; 21 days; once daily) has a significant improvement in arthritis symptoms in CIA mice. The damage of each of the 4 paws in mice is divided into 0-4 to calculate the total score of the limbs. After 21 days’ oral treatment, BTK030 reduces the arthritic score to 3.62 while the control group shows a value of 8.33 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: DBA/1J mice injected with collagen as a CIA model Dosage: 30 mg/kg Administration: oral gavage; 21 days; once daily Result: Decreased arthritis scores significantly when it compares to control group.

Form:Solid

IC50& Target:IC50: Bruton kinase (BTK)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment.

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 441.48

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (113.26 mM; Need ultrasonic)