D-erythro-sphingosine-1-phosphate (C20 base) - Moligand™, ≥99% , Agonist of S1P 2 receptor, CAS No.799812-75-2, Agonist of S1P 2 receptor

CAS: 799812-75-2 Cat. No.: D130702 Molecular Weight: 407.52

GRADE & PURITY Moligand™, ≥99%

Synonyms

(2S,3R,4E)-2-Azaniumyl-3-hydroxyicos-4-en-1-yl hydrogen phosphate | GTPL11496 | [(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate | Sphingosine-1-Phosphate (d20:1), D-erythro-sphingosine-1-phosphate (C20 base), powder | D-erythro-Sphingosine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

product description：

Sphingosine-1-phosphate (S1P) is a zwitterionic sphingolipid. It is found in insects, yeasts and plants. Sphingosine-1-Phosphate (d20:1) is a phosphorylated derivative of long chain base C20 sphingosine.

application：

Sphingosine-1-phosphate (S1P)-d7 has been used as a reference standard in liquid chromatography/tandem mass spectrometry analysis for quantitative analyses of S1P d20:1 in central nervous system of healthy mice and in human glioblastoma tissue.

Biochemical mechanism:

Sphingosine-1-phosphate (S1P) is an important cellular metabolite and signaling lipid in animal cells. It aids in various physiological and cellular processes such as atherosclerosis, inflammation, immunity, tumorigenesis, and cell proliferation. S1P plays a vital role in mammalian brain and cardiac development. S1P d20:1 serves as a partial agonist at the S1P receptor 2 (S1P2). It has an ability to inhibit S1P d18:1‐mediated cyclooxygenase 2(COX2) induction.

Specifications

Synonyms

(2S, 3R, 4E)-2-Azaniumyl-3-hydroxyicos-4-en-1-yl hydrogen phosphate | GTPL11496 | [(E, 2S, 3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate | Sphingosine-1-Phosphate (d20:1), D-erythro-sphingosine-1-phosphate (C20 base), powder | D-erythro-Sphingosine

Specifications & Purity

Moligand™, ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of S1P 2 receptor

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CCCCCCCCCCCCCCCC=CC(C(COP(=O)(O)[O-])[NH3+])O
• IUPAC Name: [(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate
• InChIKey: YUUWWSOTAGQJFW-YIVRLKKSSA-N
• INCHI: 1S/C20H42NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)19(21)18-26-27(23,24)25/h16-17,19-20,22H,2-15,18,21H2,1H3,(H2,23,24,25)/b17-16+/t19-,20+/m0/s1
• Isomeric SMILES: CCCCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)[O-])[NH3+])O
• Molecular Weight: 407.52
• Reaxy-Rn: 35857216
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35857216&ln=

Associated Targets(Human)

S1PR2 Tchem Sphingosine 1-phosphate receptor 2 (0 Activities)

Discover Target: S1PR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)