GRADE & PURITY 10mM in DMSO

Synonyms

RG7741 | Cyclopropanecarboxam​ide, N-​[4-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​5-​bromo-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

GDC-0575 (ARRY-575, RG7741) is a potent and selectiveCHK1inhibitor with an IC50 of 1.2 nM.
In vitro

GDC-0575 enhances the cytotoxicity of Cytarabine (AraC) in vitro.

In vivo

GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor that results in tumor shrinkage and growth delay in xenograft models.
Cell Data

cell lines：various cancer cell lines belonging to 4 types of cancer—breast, ovarian, prostate, and endometrial cancer—in which the PIK3CA mutation and PTEN deficiency are frequently found and in which RAS/RAF is rarely mutated

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

RG7741 | Cyclopropanecarboxam​ide, N-​[4-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​5-​bromo-​1H-​pyrrolo[2, ​3-​b]​pyridin-​3-​yl]​-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2\u2009nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Product Properties

• ALogP: 1.621
• hba_count: 2
• HBD Count: 3
• Rotatable Bond: 3

Names and Identifiers

• Isomeric SMILES: C1C[C@H](CN(C1)C2=C3C(=CNC3=NC=C2Br)NC(=O)C4CC4)N
• Molecular Weight: 378.27
• Reaxy-Rn: 39067843
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39067843&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 7 mg/mL (28.84 mM); Ethanol: 5 mg/mL (20.6 mM); Water: Insoluble
• DMSO(mg / mL) Max Solubility: 75
• DMSO(mM) Max Solubility: 198.271076215402
• Water(mg / mL) Max Solubility: ＜1