Icaritin - 10mM in DMSO , CAS No.118525-40-9

CAS: 118525-40-9 Cat. No.: I420814 Molecular Weight: 368.38
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Synonyms
Icartin | UFE666UELY | 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one | Icaritin | UNII-UFE666UELY | ICARITIN [WHO-DD] | TUUXBSASAQJECY-UHFFFAOYSA-N | Formaldehyd | AC-33950 | 4H-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyp
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
I420814-1ml
1
$64.90
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii; enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway.

Specifications

Synonyms
Icartin | UFE666UELY | 3, 5, 7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one | Icaritin | UNII-UFE666UELY | ICARITIN [WHO-DD] | TUUXBSASAQJECY-UHFFFAOYSA-N | Formaldehyd | AC-33950 | 4H-1-benzopyran-4-one, 3, 5, 7-trihydroxy-2-(4-methoxyp
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Antiproliferative agent (IC 50 values are 8, 13 and 18 μM for K562, CML-CP and CML-BC cells respectively). Inhibits H/R-induced PTK activation. Induces G(2)/M cell cycle arrest and mitochondrial transmembrane potential drop.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Canonical SmilesCC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C
IUPAC Name3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
InChIKeyTUUXBSASAQJECY-UHFFFAOYSA-N
INCHI1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
Isomeric SMILES CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C
WGK Germany 3
Molecular Weight 368.38
Reaxy-Rn 347627
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=347627&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids
SubclassFlavones
Intermediate Tree Nodes Not available
Direct Parent8-prenylated flavones
Alternative Parents 4'-O-methylated flavonoids  Flavonols  3-hydroxyflavonoids  5-hydroxyflavonoids  7-hydroxyflavonoids  Chromones  Phenoxy compounds  Methoxybenzenes  Anisoles  1-hydroxy-2-unsubstituted benzenoids  Pyranones and derivatives  Alkyl aryl ethers  Vinylogous acids  Heteroaromatic compounds  Oxacyclic compounds  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 8-prenylated flavone - 4p-methoxyflavonoid-skeleton - 3-hydroxyflavone - 3-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Chromone - Benzopyran - 1-benzopyran - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Pyranone - Phenol - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Pyran - Monocyclic benzene moiety - Vinylogous acid - Heteroaromatic compound - Oxacycle - Organoheterocyclic compound - Polyol - Ether - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Organic oxide - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 8-prenylated flavones. These are flavones that features a C5-isoprenoid substituent at the 8-position.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMMC-7721 (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hep 3B2 (2332 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
PDE6C Phosphodiesterase 6C (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus cereus (7522 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SensitivityHeat Sensitive
Melt Point(°C)233°C
Molecular Weight368.400 g/mol
XLogP34.800
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass368.126 Da
Monoisotopic Mass368.126 Da
Topological Polar Surface Area96.200 Ų
Heavy Atom Count27
Formal Charge0
Complexity612.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Kaijia Zhang, Jian Dong, Jun Lu, Lan Li, Huan Liang, Jing Jin, Peng Wang, Xiaolian Sun, Qing Jiang.  (2022)  Icaritin-Incorporated Porous Hollow Iron Oxide Nanostructures for Promoting Fracture Repair.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.2c00660]
2. Song Wang, Xinnan Chang, Jing Li, Zuoqiao Shi, Guowen Li.  (2025)  Identification of chemical components and metabolites in rats after oral administration of Epimedium-Astragalus granule pair by liquid chromatography-high resolution mass spectrometry combined with diagnostic fragment ions and mass defect filtering.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:40014893] [10.1016/j.jpba.2025.116768]
3. Jiaojiao Ding, Tiexiang Gao, Songlin Liu, Zhezhe Li, Baifei Hu, Junping Zhen, Xiaowei Yao, Hongtao Liu, Haiming Hu.  (2025)  Rhamnosidase from Parabacteroides distasonis exhibit the catabolism of epimedin C in the human gut microbiota.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40157660] [10.1016/j.ijbiomac.2025.142481]
4. Jiali Tang, Yanlu Chen, Hao Lai, Qi Zeng, Yu Li, Junqi Feng, Ningjing Lin, Ronghua Jin, Junjie Liu, Tao Luo, Zixuan Liang.  (2025)  Innovative immunosonogen nanoplatform combining sonodynamic oxygenation and immunomodulation for superior cancer therapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163582]
5. Anyi Wu, Junping Zhou, Yinan Xue, Yun Liu, Jidong Shen, Xin Gao, Zhiqiang Liu, Yuguo Zheng.  (2025)  Efficient multi-enzyme system for icaritin production from naringenin with synchronous prenol utilization in Escherichia coli.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41314575] [10.1016/j.ijbiomac.2025.149283]
Solution Calculators
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