IEM 1754 2HBr - 10mM in DMSO , CAS No.162831-31-4

CAS: 162831-31-4 Cat. No.: I408481 Molecular Weight: 412.2 PubChem CID: 9887867

GRADE & PURITY 10mM in DMSO

Synonyms

1,5-Pentanediamine, N1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrobromide (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

IEM 1754 2HBr is a selective AMPA/kainate receptor blockers forGluR1andGluR3withIC50of 6 μM.
In vitro

IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Synonyms

1, 5-Pentanediamine, N1-(tricyclo[3.3.1.13, 7]dec-1-ylmethyl)-, hydrobromide (1:2)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1C2CC3CC1CC(C2)(C3)CNCCCCCN.Br.Br
• PubChem CID: 9887867
• Molecular Weight: 412.2

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.22 mM); Ethanol: 5 mg/mL (17.17 mM); Water: Insoluble