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Ivacaftor-d4 - ≥96% , CAS No.I658675
AVAILABLE TO ORDER
GRADE & PURITY ≥96%
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
≥96% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor ( HY-13017 ). Ivacaftor is a potent and orally active CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC 50 s of 100 nM and 25 nM, respectively.
Appearance:Solid
In Vitro:Ivacaftor (10 μM) increases the PC secretion activity by 3-fold for ABCB4-G535D, 13.7-fold for ABCB4-G536R, 6.7-fold for ABCB4-S1076C, 9.4-fold for ABCB4-S1176L, and 5.7-fold for ABCB4-G1178S. Ivacaftor corrects the functional defect of ABCB4 mutants
In Vivo:Ivacaftor (1-200mg/kg, p.o.) exhibits good oral bioavailability in rat. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological Activity:Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor ( HY-13017 ). Ivacaftor is a potent and orally active CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC 50 s of 100 nM and 25 nM, respectively .
Specifications
Specifications & Purity
≥96%
Storage
Store at 2-8°C, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
AGONIST
Purity
≥96%
Names and Identifiers
| Molecular Weight | 396.52 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Solution Calculators
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