JAK-IN-23 - ≥98% , CAS No.J658828

CAS: J658828 Cat. No.: J658828 Molecular Weight: 441.35

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB . JAK-IN-23 can inhibit JAK1/2/3 with IC 50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF

Appearance:Solid

IC50& Target:JAK1 8.9 nM (IC 50 ) JAK2 15 nM (IC 50 ) JAK3 46.2 nM (IC 50 ) NF-κB 150.7 nM (IC 50 ) ISG 3.3 nM (IC 50 )

In Vitro:JAK-IN-23 inhibits JAK1/2/3 with IC 50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 shows potent inhibitory activities against ISG and NF-KB with IC 50 values of 3.3 nM and 150.7 nM, respectively. WB--- JAK-IN-23 (0.33μM, 1μM, 3μ

In Vivo:JAK-IN-23 (1-5mg/kg, oral) produces a strong anti-inflammatory activity in both dextran sulfate sodium (DSS) - and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute enteritis models and restores the structural composition of gut microbiota. MC

Biological Activity:JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB . JAK-IN-23 can inhibit JAK1/2/3 with IC 50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 441.35

Chemical and Physical Properties

• Solubility: DMSO : 5 mg/mL (11.33 mM; ultrasonic and warming and heat to 80°C)