JMV 2959 hydrochloride - ≥98% , CAS No.2448414-54-6

CAS: 2448414-54-6 Cat. No.: J650413 Molecular Weight: 545.08

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a ( GHS-R 1a ) antagonist with an IC 50 of 32±3 nM in LLC-PK 1 cells.

In Vitro

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R 1a ) antagonist with an IC 50 of 32 nM. JMV 2959 does not induce any intracellular calcium mobilization by itself. The dissociation constant of the receptor/JMV 2959 complex is determined by the Schild method. This experiment reveals a dissociation constant Kb of 19±6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intraperitoneal (i.p.) administration of Ghrelin (0.033, 0.1, and 0.33 mg/kg) does not alter the acoustic startle responses (ASR) or prepulse inhibition (PPI) in rats. Conversely, i.p. injection of JMV 2959 (1, 3, and 6 mg/kg), dose dependently decrease the ASR and increase PPI. Pretreatment with JMV 2959 at a dose with no effect on ASR or PPI per se, completely blocks Phencyclidine (PCP)-induced (2 mg/kg) deficits in PPI while pretreatment with the highest dose of Ghrelin does not potentiate or alter PPI responses of a sub-threshold dose of PCP (0.75 mg/kg). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal administration

Rats Two-hundred-gram male Sprague-Dawley rats are used in the study. The animals (n=15) are randomly assigned to an initial treatment dose or vehicle and subsequently receive all the different doses tested in a counter balanced design. Each test is separated by a 3- to 4-day-long washout period. The rats are given the i.p. injection of JMV 2959 (1, 3, and 6 mg/kg) (or vehicle) 17 min prior to being placed in the startle cages (i.e., 25 min prior to the first pulse) . aladdin has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 32±3 nM (GHS-R 1a , in LLC-PK 1 cells)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a ( GHS-R 1a ) antagonist with an IC 50 of 32±3 nM in LLC-PK 1 cells.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥98%

Names and Identifiers

• Molecular Weight: 545.08

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (458.65 mM; Need ultrasonic) H2O : 25 mg/mL (45.86 mM; Need ultrasonic)