p-Ethynylphenylalanine - 10mM in DMSO , CAS No.278605-15-5

CAS: 278605-15-5 Cat. No.: P656480 Molecular Weight: 189.21 PubChem CID: 25216972

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM

In Vitro

p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT 1 , 5-HT 2 , 5-HT 4 , 5-HT 5 , 5-HT 6 , and 5-HT 7 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue . p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200 g) Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

IC50& Target:Ki: 32.6 μM (TPH)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C#CC1=CC=C(C=C1)C[C@@H](C(=O)O)N
• Alternate CAS: 278605-15-5
• PubChem CID: 25216972
• MeSH Entry Terms: p-ethynylphenylalanine;pEPA cpd
• Molecular Weight: 189.21