PGF1α (Prostaglandin F1α) - Moligand™, ≥98% , Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4, CAS No.745-62-0, Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4

CAS: 745-62-0 Cat. No.: P336179 Molecular Weight: 356.50 Beilstein Registry Number: 2704846

GRADE & PURITY Moligand™, ≥98%

Synonyms

DTXSID901339475 | prostaglandin F1a | (13E,15S)-9alpha,11alpha,15-trihydroxyprost-13-en-1-oic acid | PGF1 | 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]cyclopentyl]heptanoic acid | C06475 | PGF1alpha | 3,5-dihydroxy-2-(3-hydroxy-1-oct

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Prostaglandin F1α (PGF1α) is a biosynthesis product from dihomo-γ-linolenic acid (DGLA) via the cyclooxygenaze (COX) pathway, and is a stable metabolite of prostacyclin (PGI2; sc-201231). By measuring the olfactory sensitivity of male salmon to F-type prostaglandins, studies show there is a possibility that they have a pheromonal role in Atlantic salmon. This compound also acts as smooth muscle relaxant, however, PGF1α is only half as active as PGF2α in inducing human respiratory smooth muscle contractions|in vitro|.

Specifications

Synonyms

DTXSID901339475 | prostaglandin F1a | (13E, 15S)-9alpha, 11alpha, 15-trihydroxyprost-13-en-1-oic acid | PGF1 | 7-[(1R, 2R, 3R, 5S)-3, 5-dihydroxy-2-[(1E, 3S)-3-hydroxyoct-1-en-1-yl]cyclopentyl]heptanoic acid | C06475 | PGF1alpha | 3, 5-dihydroxy-2-(3-hydroxy-1-oct

Specifications & Purity

Moligand™, ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O
• IUPAC Name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]heptanoic acid
• InChIKey: DZUXGQBLFALXCR-CDIPTNKSSA-N
• INCHI: 1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
• Isomeric SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1CCCCCCC(=O)O)O)O)O
• WGK Germany: 3
• RTECS: GY4569700
• Molecular Weight: 356.50
• Beilstein: 2704846
• Reaxy-Rn: 3121650
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3121650&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Prostaglandins and related compounds
• Alternative Parents: Long-chain fatty acids Fatty alcohols Hydroxy fatty acids Cyclopentanols Cyclic alcohols and derivatives Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Prostaglandin skeleton - Long-chain fatty acid - Fatty alcohol - Hydroxy fatty acid - Cyclopentanol - Cyclic alcohol - Secondary alcohol - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Hydrocarbon derivative - Organooxygen compound - Organic oxide - Alcohol - Organic oxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid.
• External Descriptors: Prostaglandins

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CATSPER4 Tchem Cation channel sperm-associated protein 4 (1 Activities)

Discover Target: CATSPER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER1 Tchem Cation channel sperm-associated protein 1 (1 Activities)

Discover Target: CATSPER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER3 Tchem Cation channel sperm-associated protein 3 (1 Activities)

Discover Target: CATSPER3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER2 Tchem Cation channel sperm-associated protein 2 (1 Activities)

Discover Target: CATSPER2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cruzipain (33337 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in ethanol (50 mg/ml), water (>2 mg/ml) at 25° C, PBS (pH 7.2) (2.1 mg/ml), DMSO (50 mg/ml), and DMF (50 mg/ml).
• Sensitivity: Moisture sensitive
• Refractive Index: n20D1.56
• Boil Point(°C): ~526.6° C at 760 mmHg (Predicted)
• Melt Point(°C): 95-97° C
• Molecular Weight: 356.500 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 13
• Exact Mass: 356.256 Da
• Monoisotopic Mass: 356.256 Da
• Topological Polar Surface Area: 98.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 396.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1