(R)-MG132 - ≥98% , CAS No.1211877-36-9

CAS: 1211877-36-9 Cat. No.: R166528 Molecular Weight: 475.62

GRADE & PURITY ≥98%

Synonyms

(R)-MG 132 | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product Application:

(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor

Specifications

Synonyms

(R)-MG 132 | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Potent 20S proteasome inhibitor (IC50= 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cellsin vitro.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488201152
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488201152
• Canonical Smiles: CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
• IUPAC Name: benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
• InChIKey: TZYWCYJVHRLUCT-ZRBLBEILSA-N
• INCHI: 1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
• Isomeric SMILES: CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
• Molecular Weight: 475.62
• Reaxy-Rn: 11627647
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11627647&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Leucine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Benzyloxycarbonyls N-acyl amines Carbamate esters Secondary carboxylic acid amides Organonitrogen compounds Organic oxides Hydrocarbon derivatives Aldehydes
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha-dipeptide - Leucine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Benzyloxycarbonyl - Monocyclic benzene moiety - Fatty acyl - Benzenoid - N-acyl-amine - Fatty amide - Carbamic acid ester - Secondary carboxylic acid amide - Carboxamide group - Aldehyde - Organonitrogen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

VCP Tchem Transitional endoplasmic reticulum ATPase (895 Activities)

Discover Target: VCP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

EMT6 (738 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 47.56, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.51, Max Conc. mM: 20
• Molecular Weight: 475.600 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 15
• Exact Mass: 475.305 Da
• Monoisotopic Mass: 475.305 Da
• Topological Polar Surface Area: 114.000 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 644.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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2. Liyun Zheng, Zhongwei Zhao, Li Chen, Wenjing Yang, Giorgio Ercolani, Pan Qin, Bin Lin, Mengzhu Han, Qiaoyou Weng, Yeyu Zhang, Bin Wu, Minjiang Chen, Zouying Yao, Shiji Fang, Jiansong Ji.  (2025)  Astragalin Induces Immunogenic Cell Death in Liver Cancer by Targeting NQO2 to Promote ROS-Mediated Endoplasmic Reticulum Stress Pathway.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:40749898] [10.1016/j.freeradbiomed.2025.07.047]

3. Leyao Chen, Xinluan Lv, Xiaoyu Chang, Ruiyong Wang.  (2025)  Synthesis and Evaluation of Thiosemicarbazone Inhibitors for SARS-CoV-2 Mpro by Spectroscopy and Microscale Thermophoresis.  ARCHIV DER PHARMAZIE,  358  (9): (e70089).  [PMID:40922402] [10.1002/ardp.70089]

4. Daohui Gong, Xueping Liu, Pengfei Wu, Yue Chen, Yuhang Xu, Zhan Gao, Hang Qian, Guansong Wang, Binfeng He.  (2023)  Rab26 alleviates sepsis-induced immunosuppression as a master regulator of macrophage ferroptosis and polarization shift.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:38169213] [10.1016/j.freeradbiomed.2023.12.046]

5. Xingkang Diao, GuoHua Qi, Xinli Li, Yu Tian, Jing Li, Yongdong Jin.  (2025)  Label-Free Exosomal SERS Detection Assisted by Machine Learning for Accurately Discriminating Cell Cycle Stages and Revealing the Molecular Mechanisms during the Mitotic Process.  ANALYTICAL CHEMISTRY,      [PMID:39999424] [10.1021/acs.analchem.4c06240]

6. Runyu Dong, Yao Fei, Yiren He, Peng Gao, Bo Zhang, Menglin Zhu, Zhixiong Wang, Longfei Wu, Shuai Wu, Xiaoming Wang, Juan Cai, Zhiqiang Chen, Xueliang Zuo.  (2025)  Lactylation-Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib.  Advanced Science,      [PMID:39976163] [10.1002/advs.202412559]

7. Huang Wenji, Wang Yafang, Ji Ning, Xiao Hehe, Chen Kangyong, Guo Jiahong, Feng Jianhua, Mustafa Nageen, Wang Junya, Feng Hao, Zou Jun.  (2025)  Zebrafish TRIM2a promotes virus replication via ubiquitination of IRF3 and autophagic cargo receptor p62.  JOURNAL OF IMMUNOLOGY,      [PMID:40359380] [10.1093/jimmun/vkaf064]

8. Chenchen Zhao, Yan Qin, Haixin Huang, Yuying Li, Xinyu Zhang, Lin Zhou, Lulu Xie, Yimin Zhou, Yanqing Hu, Wei Chen, Tian Lan, Wen-Chao Sun.  (2025)  BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway.  Microorganisms,  13  (8): (1865).  [PMID:40871369] [10.3390/microorganisms13081865]