10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 ( MC-4 ) receptor antagonist. SNT207858 free base has an IC 50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor
In Vitro
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model Dosage: 30 mg/kg Administration: Oral administration; once daily; 15 days Result: Significantly reduced the tumor induced weight loss.
IC50& Target:MC-4 receptor
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 ( MC-4 ) receptor antagonist. SNT207858 free base has an IC 50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
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