≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
ThioLox is a competitive 15-lipoxygenase-1 ( 15-LOX-1 ) inhibitor with a K i of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties
In Vitro
ThioLox shows competitive inhibition thus indicating non-covalent interaction with the active site of the 15-LOX-1. ThioLox (50 μM; 24 h) inhibits interleukin (IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS) expression in precision-cut lung slices (PCLS). ThioLox (10 μM; 16 h) prevent lipid peroxidation and mitochondrial superoxide formation in neuronal cells. ThioLox (5-20 μM; 14-16 h) protects HT-22 cells against glutamate toxicity and significantly reduces neuronal cell death. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: Precision-cut lung slices (PCLS) Concentration: 1, 5, 10, 25 and 50 μM Incubation Time: In combination with 10 μM linoleic acid for 20 h and stimulated with 10 ng/mL LPS for the last 4 h. Result: Provided almost 50% inhibition of the expression of the pro-inflammatory genes IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS at 50 μM. Cell Viability AssayCell Line: Neuronal HT-22 cells Concentration: 5, 10 and 20 μM Incubation Time: 14-16 h Result: Significantly reduced neuronal cell death against glutamate toxicity.
In Vivo
ThioLox has a logP of 3 and shows values that comply very well with the BBB permeability . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Ki: 3.30 μM (15-LOX-1)
| Canonical Smiles | CCCCNC(=O)C1=C(SC(=C1)C2=CC=CC=C2)N |
|---|---|
| IUPAC Name | 2-amino-N-butyl-5-phenylthiophene-3-carboxamide |
| InChIKey | QWWMJRJCSZMXHZ-UHFFFAOYSA-N |
| INCHI | 1S/C15H18N2OS/c1-2-3-9-17-15(18)12-10-13(19-14(12)16)11-7-5-4-6-8-11/h4-8,10H,2-3,9,16H2,1H3,(H,17,18) |
| Isomeric SMILES | CCCCNC(=O)C1=C(SC(=C1)C2=CC=CC=C2)N |
| PubChem CID | 53383638 |
| Molecular Weight | 274.38 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Thiophenes |
| Subclass | Thiophene carboxylic acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Thiophene carboxamides |
| Alternative Parents | 2,3,5-trisubstituted thiophenes Benzene and substituted derivatives 2-aminothiophenes Vinylogous amides Heteroaromatic compounds Secondary carboxylic acid amides Amino acids and derivatives Primary amines Organooxygen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Thiophene carboxamide - 2,3,5-trisubstituted thiophene - Monocyclic benzene moiety - Benzenoid - 2-aminothiophene - Vinylogous amide - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as thiophene carboxamides. These are compounds containing a thiophene ring which bears a carboxamide. |
| External Descriptors | Not available |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Solubility | DMSO : 100 mg/mL (364.46 mM; ultrasonic and warming and heat to 60°C) |
|---|---|
| Molecular Weight | 274.400 g/mol |
| XLogP3 | 4.000 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 274.114 Da |
| Monoisotopic Mass | 274.114 Da |
| Topological Polar Surface Area | 83.400 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 292.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
