1-Methylpiperazine - ≥99% , CAS No.109-01-3

CAS: 109-01-3 Cat. No.: M108683 Molecular Weight: 100.16 Beilstein Registry Number: 102724 EC Number: 203-639-5
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Synonyms
InChI=1/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H | N-(methyl)piperazine | STK506426 | Z57834041 | NSC30195 | NSC-30195 | SCHEMBL1363 | EC 203-639-5 | STR00448 | 1-Methylpiperazine, 99% | BCP29604 | 1-Methylpiperazine | 1-Methyl-piperazine | 4-methylpiperazin
Storage
Room temperature,Desiccated,Cool
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25ml
M108683-25ml
2
$9.90
100ml
M108683-100ml
2
$18.90
500ml
M108683-500ml
3
$55.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature,Desiccated,Cool Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
InChI=1/C5H12N2/c1-7-4-2-6-3-5-7/h6H, 2-5H2, 1H | N-(methyl)piperazine | STK506426 | Z57834041 | NSC30195 | NSC-30195 | SCHEMBL1363 | EC 203-639-5 | STR00448 | 1-Methylpiperazine, 99% | BCP29604 | 1-Methylpiperazine | 1-Methyl-piperazine | 4-methylpiperazin
Specifications & Purity
≥99%
Storage
Room temperature, Desiccated, Cool
Shipped In
Normal
Purity
≥99%
Names and Identifiers
Pubchem Sid504753673
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504753673
Canonical SmilesCN1CCNCC1
IUPAC Name1-methylpiperazine
InChIKeyPVOAHINGSUIXLS-UHFFFAOYSA-N
INCHI1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3
Isomeric SMILES CN1CCNCC1
WGK Germany 2
RTECS TM1225000
UN Number 2734
Packing Group II
Molecular Weight 100.16
Beilstein 102724
Reaxy-Rn 102724
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=102724&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassDiazinanes
SubclassPiperazines
Intermediate Tree Nodes N-alkylpiperazines
Direct ParentN-methylpiperazines
Alternative Parents Trialkylamines  Dialkylamines  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents N-methylpiperazine - Tertiary aliphatic amine - Tertiary amine - Azacycle - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Amine - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as n-methylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries a methyl group.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(non-human)
Aspergillus nidulans (364 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus flavus (8875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pichia kudriavzevii (7448 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nakaseomyces glabratus (9108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida parapsilosis (8521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

29 results found

Lot NumberCertificate TypeDateItem
C2631356Certificate of AnalysisApr 07, 2026 M108683
C2631357Certificate of AnalysisApr 07, 2026 M108683
C2631358Certificate of AnalysisApr 07, 2026 M108683
C2631360Certificate of AnalysisApr 07, 2026 M108683
F2502123Certificate of AnalysisJun 09, 2025 M108683
B2626044Certificate of AnalysisJun 06, 2025 M108683
E2527389Certificate of AnalysisJun 06, 2025 M108683
E2527582Certificate of AnalysisJun 06, 2025 M108683
E2527583Certificate of AnalysisJun 06, 2025 M108683
E2527584Certificate of AnalysisJun 06, 2025 M108683
C2525347Certificate of AnalysisApr 03, 2025 M108683
C2525348Certificate of AnalysisApr 03, 2025 M108683
H2430167Certificate of AnalysisSep 07, 2024 M108683
H2430168Certificate of AnalysisSep 07, 2024 M108683
H2430169Certificate of AnalysisSep 07, 2024 M108683
H2430535Certificate of AnalysisSep 07, 2024 M108683
J2326579Certificate of AnalysisNov 07, 2023 M108683
J2326578Certificate of AnalysisNov 07, 2023 M108683
J2326577Certificate of AnalysisNov 07, 2023 M108683
J2326576Certificate of AnalysisNov 07, 2023 M108683
J2222388Certificate of AnalysisOct 28, 2022 M108683
J2222389Certificate of AnalysisOct 26, 2022 M108683
J2222415Certificate of AnalysisOct 26, 2022 M108683
I2228230Certificate of AnalysisOct 10, 2022 M108683
I2228228Certificate of AnalysisOct 10, 2022 M108683
G2201458Certificate of AnalysisJul 21, 2022 M108683
G2201457Certificate of AnalysisJul 21, 2022 M108683
G2201456Certificate of AnalysisJul 21, 2022 M108683
G2201455Certificate of AnalysisJul 21, 2022 M108683

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Chemical and Physical Properties
SolubilitySolubility in water: Completely miscible
SensitivityHygroscopic
Refractive Index1.4655
Flash Point(°F)107.6℉
Flash Point(°C)42℃
Boil Point(°C)138°C
Melt Point(°C)-6.4°C
Molecular Weight100.160 g/mol
XLogP3-0.400
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass100.1 Da
Monoisotopic Mass100.1 Da
Topological Polar Surface Area15.300 Ų
Heavy Atom Count7
Formal Charge0
Complexity48.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Yuhao Han, Xinyan Qu, Haoyuan Geng, Lei Wang, Zihan Zhu, Yaqi Zhang, Xiaoqing Cui, Heng Lu, Xiao Wang, Panpan Chen, Quanbo Wang, Chenglong Sun.  (2023)  Isotope-Coded On-Tissue Derivatization for Quantitative Mass Spectrometry Imaging of Short-Chain Fatty Acids in Biological Tissues.  ANALYTICAL CHEMISTRY,      [PMID:37997359] [10.1021/acs.analchem.3c03308]
2. Song Wang, Yan Wang, Yanchao Zhang, Zhiyan Sui, Junjian Yu, Jialin Zhao, Na Li, Yifang Chang, Di Liu, Zhe Wang.  (2023)  Synergistic interaction and alkali resistance of N-spirocyclic cations with piperidine cations for poly(biphenyl piperidine) membranes.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.121986]
3. D.-Y. Li, Y.-H. Liu, Q. Wang, X.-W. Lei, C.-Y. Yue, Z.-H. Jing.  (2023)  Zero-dimensional hybrid zinc halides with blue light emissions.  Materials Today Chemistry,      [PMID:] [10.1016/j.mtchem.2023.101604]
4. Ke Wang, Liru An, Ganghui Lu, Jialu Zhang, Zilong Wang, Meiyu Si, Guiyan Liu, Yongfei Zeng.  (2023)  Effect of heterocyclic substituents on the thermo/pH/CO2-responsiveness of multistimuli-responsive homopolymers.  POLYMER,      [PMID:] [10.1016/j.polymer.2023.126039]
5. Yihao Chen, Lei Zhou, Shuigen Zhou, Donghui You, Haizhou Xiong, Yuhan Hu, Qinlin Chen, Rongxing He, Ming Li.  (2023)  Effect of the Host Lattice Environment on the Expression of 5s2 Lone-Pair Electrons in a 0D Bismuth-Based Metal Halide.  INORGANIC CHEMISTRY,      [PMID:36716166] [10.1021/acs.inorgchem.2c03961]
6. Nan He, Pifu Gong, Xingyu Zhang, Youquan Liu, Linfeng Dong, Zheshuai Lin.  (2023)  (C5N2H14)GeBr4: A 2D Organic Germanium Bromide Perovskite with Strong Orange Photoluminescence Properties.  INORGANIC CHEMISTRY,      [PMID:36602526] [10.1021/acs.inorgchem.2c03432]
7. Lihua Zhou, Yang He, Shaohua Gou, Qin Zhang, Ling Liu, Lan Tang, Xianzhi Zhou, Ming Duan.  (2019)  Efficient inhibition of montmorillonite swelling through controlling flexibly structure of piperazine-based polyether Gemini quaternary ammonium salts.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2019.123190]
8. Yugui Han, Yefei Wang, Xianghai Meng, Qiuxia Wang, Xiaodong Han.  (2019)  Wormlike micelles with a unique ladder shape formed by a C22-tailed zwitterionic surfactant bearing a bulky piperazine group.  Soft Matter,  15  (38): (7644-7653).  [PMID:31486473] [10.1039/C9SM01358J]
9. Dongdong Yao, Ting Li, Yaping Zheng, Zhilin Zhang.  (2019)  Fabrication of a functional microgel-based hybrid nanofluid and its application in CO2 gas adsorption.  REACTIVE & FUNCTIONAL POLYMERS,      [PMID:] [10.1016/j.reactfunctpolym.2018.12.025]
10. Fei Liu, Mengxiang Fang, Wenfeng Dong, Tao Wang, Zhixiang Xia, Qinhui Wang, Zhongyang Luo.  (2018)  Carbon dioxide absorption in aqueous alkanolamine blends for biphasic solvents screening and evaluation.  APPLIED ENERGY,      [PMID:] [10.1016/j.apenergy.2018.10.007]
11. Zhao Yingyuan, Li Xiyou.  (2013)  Aggregation behavior of naphthalimide fluorescent surfactants in aqueous solution.  COLLOID AND POLYMER SCIENCE,  292  (3): (687-698).  [PMID:] [10.1007/s00396-013-3100-0]
12. Wenjun Fang, Dongbei Shao, Xiaoxing Lu, Yongsheng Guo, Li Xu.  (2012)  Extraction of Aromatics from Hydrocarbon Fuels Using N-Alkyl Piperazinium-Based Ionic Liquids.  ENERGY & FUELS,      [PMID:] [10.1021/ef201955n]
13. Yuchao Li, Nan He, Bohui Xu, Linfeng Dong, Xingyu Zhang, Jing Xu, Pifu Gong, Zheshuai Lin.  (2024)  Synthesis, Structure, and Optical Properties of a 0D Hybrid Organic–Inorganic Metal Halide (C5N2H14Cl)GeCl3.  INORGANIC CHEMISTRY,      [PMID:38381086] [10.1021/acs.inorgchem.4c00091]
14. Xiaoqian Jiang, Aihua Qu, Xinxin Xu, Hua Kuang, Liqiang Liu, Chuanlai Xu.  (2024)  Ultrasensitive detection of imatinib in human serum using a gold-based paper sensor.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:38281369] [10.1016/j.jchromb.2024.124001]
15. Hongyuan Yan, Fang Wang, Dandan Han, Gengliang Yang.  (2012)  Simultaneous determination of four plant hormones in bananas by molecularly imprinted solid-phase extraction coupled with high performance liquid chromatography.  ANALYST,  137  (12): (2884-2890).  [PMID:22553770] [10.1039/C2AN35362H]
16. Juxiang Ruan, Xiongjun Zuo, Qiwei Lang, Zhijian Zeng, Chao Li.  (2013)  Preparation of a dibenzylated 1,4-diazacyclohexane-derived strong anion-exchange stationary phase.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:23721810] [10.1016/j.chroma.2013.04.050]
17. Yan Yan, Pengchong Wang, Ruiying Li, Ying Sun, Rui Zhang, Chuanchuan Huo, Jianfeng Xing, Yalin Dong.  (2019)  Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study.  Drug Design Development and Therapy,      [PMID:30858698] [10.2147/DDDT.S192348]
18. Lilei zhang, Ning Ma, Lin Xie, Ye Wang, Yinchao Fan, Zhiyan Xu, Jingxiao Zhang.  (2025)  Density, speed of sound, refractive index, and hydrogen bonding network in the binary system of N-Methylpiperazine and ethanolamine.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2025.128726]
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