5,5-Diphenylhydantoin sodium salt - ≥98% , CAS No.630-93-3

CAS: 630-93-3 Cat. No.: D107846 Molecular Weight: 274.25 EC Number: 211-148-2

GRADE & PURITY ≥98%

Synonyms

MLS000554076 | Phenytoin sodium (USP:JAN) | 5,5-Diphenylhydantoin sodium | Dilantin Infatabs | Dilantin Suspension | Epanutin | sodium;5,5-diphenylimidazolidin-3-ide-2,4-dione | 5,5-diphenylhydantoin sodium sigmaultra | Aladdin | Dihydan | Phenytoin sodiu

Storage

Room temperature

Shipped In

Normal

Overview

Product Describtion:

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

Product Application：

5,5-Diphenylhydantoin sodium salt has been used in the cream preparation for treating burn wounds，in seizure behavior testing as an anticonvulsant in Drosophila，in in vivo embryo toxicity test in mouse embryonic stem cells.

Specifications

Synonyms

MLS000554076 | Phenytoin sodium (USP:JAN) | 5, 5-Diphenylhydantoin sodium | Dilantin Infatabs | Dilantin Suspension | Epanutin | sodium;5, 5-diphenylimidazolidin-3-ide-2, 4-dione | 5, 5-diphenylhydantoin sodium sigmaultra | Aladdin | Dihydan | Phenytoin sodiu

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Potent multi-channel blocker. Blocks Na + , K + and Ca 2+ channels. Selectively blocks persistent INa P over shorter INa P actions. Blocks high frequency repetitive firing of action potentials. Shows anticonvulsant effects in vivo. Orally active. Reduces

Storage

Room temperature

Shipped In

Normal

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488191004
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488191004
• Canonical Smiles: C1=CC=C(C=C1)C2(C(=O)[N-]C(=O)N2)C3=CC=CC=C3.[Na+]
• IUPAC Name: sodium;5,5-diphenylimidazolidin-3-ide-2,4-dione
• InChIKey: FJPYVLNWWICYDW-UHFFFAOYSA-M
• INCHI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• Isomeric SMILES: C1=CC=C(C=C1)C2(C(=O)[N-]C(=O)N2)C3=CC=CC=C3.[Na+]
• WGK Germany: 3
• RTECS: MU1400000
• Molecular Weight: 274.25
• Reaxy-Rn: 673467
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=673467&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azolidines
      • Subclass Imidazolidines
        • Level5 Imidazolidinones
          • Level6 Imidazolidinediones
            • Level7 Hydantoins
              • Level8 Phenylhydantoins

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azolidines
• Subclass: Imidazolidines
• Intermediate Tree Nodes: Imidazolidinones - Imidazolidinediones - Hydantoins
• Direct Parent: Phenylhydantoins
• Alternative Parents: Diphenylmethanes Phenylimidazolidines Alpha amino acids and derivatives 5-monosubstituted hydantoins N-acyl ureas Carbene-type 1,3-dipolar compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Diphenylmethane - 5-phenylhydantoin - Phenylimidazolidine - Alpha-amino acid or derivatives - 5-monosubstituted hydantoin - N-acyl urea - Ureide - Benzenoid - Monocyclic benzene moiety - Carbonic acid derivative - Azacycle - Organic alkali metal salt - Organic 1,3-dipolar compound - Carbene-type 1,3-dipolar compound - Carboxylic acid derivative - Organic sodium salt - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic nitrogen compound - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic salt - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO (Slightly), Methanol (Slightly)
• Sensitivity: moisture sensitive
• Molecular Weight: 274.250 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 274.072 Da
• Monoisotopic Mass: 274.072 Da
• Topological Polar Surface Area: 47.200 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 356.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

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