6-Hydroxydopamine hydrobromide - Moligand™,≥95% , CAS No.636-00-0

CAS: 636-00-0 Cat. No.: H197233 Molecular Weight: 250.09 Beilstein Registry Number: 3713280 EC Number: 211-247-0
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
Synonyms
2,5-Dihydroxytyramine hydrobromide | HY-B1081A | SY102034 | 6-OHDA hydrobromide6-Hydroxydopamine hydrobromide | 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide | BCP25700 | NSC238469 | NSC-238469 | TWC1D4W0WB | EINECS 217-598-6 | 636-00-0 (HBr) | Q272904
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
10mg
H197233-10mg
3
$9.90
50mg
H197233-50mg
3
$29.90
250mg
H197233-250mg
3
$99.90
1g
H197233-1g
1
$259.90
5g
H197233-5g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$844.90
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Why this grade

Moligand™,≥95% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Solutions should be freshly prepared and protected from exposure to light.
6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals.


product description:

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Specifications

Synonyms
2, 5-Dihydroxytyramine hydrobromide | HY-B1081A | SY102034 | 6-OHDA hydrobromide6-Hydroxydopamine hydrobromide | 5-(2-aminoethyl)benzene-1, 2, 4-triol;hydrobromide | BCP25700 | NSC238469 | NSC-238469 | TWC1D4W0WB | EINECS 217-598-6 | 636-00-0 (HBr) | Q272904
Specifications & Purity
Moligand™, ≥95%
Biochemical and Physiological Mechanisms
Neurotoxin that destroys catecholaminergic terminals.Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels. Induces apoptosis in PC-12 cells.\xa0Destroys\xa0nigral dopaminergic neurons and their striatal terminals\xa0in rat models of
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ACTIVATOR
Note
Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥95%
Names and Identifiers
Canonical SmilesC1=C(C(=CC(=C1O)O)O)CCN.Br
IUPAC Name5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide
InChIKeyMLACDGUOKDOLGC-UHFFFAOYSA-N
INCHI1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
Isomeric SMILES C1=C(C(=CC(=C1O)O)O)CCN.Br
WGK Germany 3
RTECS DC4600000
Molecular Weight 250.09
Beilstein 3713280
Reaxy-Rn 3713280
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3713280&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassPhenols
SubclassBenzenediols
Intermediate Tree Nodes Catechols
Direct ParentCatecholamines and derivatives
Alternative Parents Phenethylamines  Hydroxyquinols and derivatives  2-arylethylamines  Aralkylamines  1-hydroxy-2-unsubstituted benzenoids  Polyols  Organopnictogen compounds  Monoalkylamines  Hydrocarbon derivatives  Hydrobromides  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Catecholamine - Hydroxyquinol derivative - Phenethylamine - 2-arylethylamine - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - Polyol - Primary amine - Amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrobromide - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as catecholamines and derivatives. These are compounds containing 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] or a derivative thereof formed by substitution.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLH Tchem DNA polymerase eta (21678 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERG Tbio Transcriptional regulator ERG (5589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EYA2 Tbio Eyes absent homolog 2 (5884 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
WRN Tbio Werner syndrome ATP-dependent helicase (8824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G6PD-6PGL Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (1761 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot NumberCertificate TypeDateItem
B2211106Certificate of AnalysisNov 05, 2025 H197233
B2211133Certificate of AnalysisNov 05, 2025 H197233
I2104257Certificate of AnalysisJun 09, 2025 H197233
J2520014Certificate of AnalysisSep 02, 2022 H197233
A2510121Certificate of AnalysisSep 02, 2022 H197233
G2504060Certificate of AnalysisSep 02, 2022 H197233
F2605182Certificate of AnalysisSep 02, 2022 H197233
F2603049Certificate of AnalysisSep 02, 2022 H197233
C2611057Certificate of AnalysisSep 02, 2022 H197233
B2311699Certificate of AnalysisSep 02, 2022 H197233
B2311698Certificate of AnalysisSep 02, 2022 H197233
B2311696Certificate of AnalysisSep 02, 2022 H197233
B2311695Certificate of AnalysisSep 02, 2022 H197233
B2311660Certificate of AnalysisSep 02, 2022 H197233
B2211337Certificate of AnalysisDec 20, 2021 H197233
B2211277Certificate of AnalysisDec 20, 2021 H197233
B2211201Certificate of AnalysisDec 20, 2021 H197233

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Chemical and Physical Properties
SolubilitySoluble in DMSO, highest concentration (mg/mL): 50, highest concentration (mM): 199.93; soluble in H2O, highest concentration (mg/mL): 50, highest concentration (mM): 199.93; soluble in Ethanol, highest concentration (mg/mL): 50, the highest concentration
SensitivityLight & Moisture & Air & Heat sensitive
Melt Point(°C)216-220°C
Molecular Weight250.090 g/mol
XLogP3
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass249 Da
Monoisotopic Mass249 Da
Topological Polar Surface Area86.700 Ų
Heavy Atom Count13
Formal Charge0
Complexity142.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Documents & Articles
Citations of This Product
References
1. Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang Ba.  (2023)  Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,      [PMID:37495085] [10.1016/j.bbadis.2023.166814]
2. Yi-Kao Hu, Yi-Ming Liu, Xiao-Lin Bai, Chao Ma, Xun Liao.  (2022)  Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36562659] [10.1021/acs.jafc.2c06630]
3. Feifei Zhu, Han Chen, Jinying Han, Weiwei Zhou, Qi Tang, Qian Yu, Shangshang Ma, Xiaoyong Liu, Shuhao Huo, Keping Chen.  (2022)  Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson’s Disease.  JOURNAL OF PROTEOME RESEARCH,      [PMID:35959672] [10.1021/acs.jproteome.2c00149]
4. Baoxiang Wang, Lihua Geng, Jing Wang, Yuxi Wei, Changhui Yan, Ning Wu, Yang Yue, Quanbin Zhang.  (2024)  Optimization of the Preparation Process of Glucuronomannan Oligosaccharides and Their Effects on the Gut Microbiota in MPTP-Induced PD Model Mice.  Marine Drugs,  22  (5): (193).  [PMID:38786584] [10.3390/md22050193]
5. Zhang Jia-qi, Li Shu-yi, Yin Cui, Ji Ying, Zhang Xiang, Liu Dan-yang, Yang Hang, Niu Yong, Cui Gui-yun, Zhou Chun-yi, Xiao Cheng.  (2025)  Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice.  ACTA PHARMACOLOGICA SINICA,      [PMID:40329003] [10.1038/s41401-025-01570-2]
6. Zuowen Zhang, Lan Shen, Yinyou Bai, Shishuang Li, Shumei Wang.  (2025)  WuMei-pill alleviates Parkinson's disease induced by dopamine neuron damage in mice by regulating the gut-brain-microbiome axis.  Journal of Radiation Research and Applied Sciences,      [PMID:] [10.1016/j.jrras.2025.101632]
7. Zang Hao-Jing, Bai Xiao-Lin, Sui Xue-Yi, Zhai Xiao-Rui, Wang Yong-Cui, Xin Zhong-Quan, Yin Qiu-Yuan, Hao Xiao-Jiang, Wang Yue-Hu, Liao Xun, Di Ying-Tong.  (2025)  Neuroprotective effects of chemical constituents from Nicotiana tabacum L. in Parkinson’s disease.  Natural Products and Bioprospecting,  15  (1): (1-13).  [PMID:41028298] [10.1007/s13659-025-00541-8]
8. Zizhao Zhai, Wenhao Wang, Guanlin Wang, Chunfu Wei, Shuhua Wei, Jinxia Li, Lingling Zheng, Xiao Yue, Chuangxin Chen, Junhuang Jiang, Bing Zhu, Ziyu Zhao, Xin Pan, Chuanbin Wu, Xuejuan Zhang.  (2026)  Rationalizing nose-to-brain drug delivery: Machine learning-guided optimization and mechanistic elucidation of olfactory deposition for nasal sprays.  JOURNAL OF CONTROLLED RELEASE,      [PMID:41617015] [10.1016/j.jconrel.2026.114667]
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