6-Thio-GTP (aqueous solution) (Thiogtp) - ≥95% , CAS No.17670-19-8

CAS: 17670-19-8 Cat. No.: T276292 Molecular Weight: 539.25 PubChem CID: 3036888

GRADE & PURITY ≥95%

Synonyms

6-Thioguanosine-5'-O-triphosphate sodium salt | 6-Thioguanosine 5'-triphosphate | 6-T-GTP | Thiogtp | [[(2R,3S,4R,5S)-5-(2-amino-6-sulfanylidene-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate | 6-Thioguanos

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Store at -20°C (desiccating conditions).

Specifications

Synonyms

6-Thioguanosine-5'-O-triphosphate sodium salt | 6-Thioguanosine 5'-triphosphate | 6-T-GTP | Thiogtp | [[(2R, 3S, 4R, 5S)-5-(2-amino-6-sulfanylidene-3H-purin-9-yl)-3, 4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate | 6-Thioguanos

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Vac-1-Rac signaling inhibitor. Azathioprine metabolite. 6-mercaptopurine derivative. Inhibits TNF-α-induced downstream signaling via JNK. Reduces c-Jun, transcription factor-2 and NF-κB activation. Shows immunosuppressant effects

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Note

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)NC(=NC2=S)N
• IUPAC Name: [[(2R,3S,4R,5S)-5-(2-amino-6-sulfanylidene-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• InChIKey: QENYANNAQSWPLM-BDXYJKHTSA-N
• INCHI: 1S/C10H16N5O13P3S/c11-10-13-7-4(8(32)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-3,5-6,9,16-17H,1H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,32)/t3-,5-,6-,9+/m1/s1
• Isomeric SMILES: C1=NC2=C(N1[C@@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)NC(=NC2=S)N
• PubChem CID: 3036888
• Molecular Weight: 539.25

Chemical and Physical Properties

• Solubility: Supplied in water (10 mM)