Aladdin™ NHS-Biotin - ≥99% , CAS No.35013-72-0

CAS: 35013-72-0 Cat. No.: A638743 Molecular Weight: 341.38 Beilstein Registry Number: 4720781 EC Number: 609-055-0

GRADE & PURITY ≥99%

Synonyms

(+)-Biotin N-succinimidyl ester | D-Biotin N-Succinimidyl Ester | Biotin-NHS ester | Biotin N-Hydroxysuccinimide Ester | Biotin-NHS | (+)-Biotin N-hydroxysuccinimide ester | Biotin-Osu | (+)-Biotin-NHS ester | N-Succinimidyl D-biotinate | N-Hydroxysuccini

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Product introduction：

The N-hydroxysuccinimide ester (NHS)-biotin modification helps in the biotinylation of the target lysine residue at its ε-amino group and identifies the surface lysine residues. It is used as a tool to identify the interaction of proteins with several biological molecules, like protein-polysaccharide interactions, protein-protein interactions, protein-nucleic acid interactions, and protein-ligand interactions. NHS-biotin may be used in the biotinylation of proteins and peptides. It is typically coupled to primary amine in the pH range of 6.5-8.5.

Specifications

Synonyms

(+)-Biotin N-succinimidyl ester | D-Biotin N-Succinimidyl Ester | Biotin-NHS ester | Biotin N-Hydroxysuccinimide Ester | Biotin-NHS | (+)-Biotin N-hydroxysuccinimide ester | Biotin-Osu | (+)-Biotin-NHS ester | N-Succinimidyl D-biotinate | N-Hydroxysuccini

Specifications & Purity

≥99%

Storage

Store at -20°C, Argon charged, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1CC(=O)N(C1=O)OC(=O)CCCCC2C3C(CS2)NC(=O)N3
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
• InChIKey: YMXHPSHLTSZXKH-RVBZMBCESA-N
• INCHI: 1S/C14H19N3O5S/c18-10-5-6-11(19)17(10)22-12(20)4-2-1-3-9-13-8(7-23-9)15-14(21)16-13/h8-9,13H,1-7H2,(H2,15,16,21)/t8-,9-,13-/m0/s1
• Isomeric SMILES: C1CC(=O)N(C1=O)OC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3
• WGK Germany: 3
• Molecular Weight: 341.38
• Beilstein: 4720781
• Reaxy-Rn: 4720780
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4720780&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Biotin and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Biotin and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Biotin and derivatives
• Alternative Parents: Thienoimidazolidines Imidazolidinones Pyrrolidine-2-ones Dicarboximides Thiophenes Thiolanes Lactams Ureas Carboxylic acid salts Monocarboxylic acids and derivatives Azacyclic compounds Dialkylthioethers Organonitrogen compounds Organic salts Organic oxides Hydrocarbon derivatives Organopnictogen compounds Carbonyl compounds
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Biotin_derivative - Biotin - Thienoimidazolidine - Imidazolidinone - Pyrrolidone - 2-pyrrolidone - Dicarboximide - Imidazolidine - Pyrrolidine - Thiolane - Thiophene - Urea - Carboxylic acid salt - Lactam - Carbonic acid derivative - Thioether - Azacycle - Dialkylthioether - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Organic salt - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Organooxygen compound - Carbonyl group - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aliphatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as biotin and derivatives. These are organic compounds containing a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMF(Dimethylformamide),DMSO(Dimethylsulfoxide)
• Sensitivity: Moisture sensitive；air sensitive；heat sensitive
• Melt Point(°C): 140°C
• Molecular Weight: 341.380 g/mol
• XLogP3: -0.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 341.105 Da
• Monoisotopic Mass: 341.105 Da
• Topological Polar Surface Area: 130.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 525.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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