Avibactam sodium hydrate - 10mM in Water , CAS No.A661645(Water)

CAS: A661645(Water) Cat. No.: A661645 Molecular Weight: 305.24

GRADE & PURITY 10mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively.

IC50& Target:IC 50 : 5 nM (CTX-M-15), 8 nM (TEM-1)

In Vitro:Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases. Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 bla KPC-2 positive and 1 of bl

In Vivo:Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model. Avibactam (64mg/kg; s.c.; once) shows mean estimated half-l

Biological Activity:Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively.

Specifications

Specifications & Purity

10mM in Water

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 305.24