BCH001 - 10mM in DMSO , CAS No.384859-58-9

CAS: 384859-58-9 Cat. No.: B423781 Molecular Weight: 420.34

GRADE & PURITY 10mM in DMSO

Synonyms

3-​Quinolinecarboxylic acid,4-​[(2-​carboxyphenyl)​amino]​-​6-​(trifluoromethoxy)​-​,3-​ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

BCH001 BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.

Targets

PAPD5

In vitro

BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in DC patient induced pluripotent stem cells.

Cell Research(from reference)

Cell lines：CD34+ HSPCs, iPSCs and fibroblasts 

Concentrations：1 μM, 5 μM, 100 μM 

Incubation Time：72 h, 5 days, 14 days 

Specifications

Synonyms

3-​Quinolinecarboxylic acid, 4-​[(2-​carboxyphenyl)​amino]​-​6-​(trifluoromethoxy)​-​, 3-​ethyl ester

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Product Properties

• ALogP: 5.52
• hba_count: 5
• HBD Count: 1
• Rotatable Bond: 8

Names and Identifiers

• Isomeric SMILES: CCOC(=O)C1=CN=C2C=CC(=CC2=C1NC3=CC=CC=C3C(=O)O)OC(F)(F)F
• Molecular Weight: 420.34
• Reaxy-Rn: 34506449
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34506449&ln=

Chemical and Physical Properties

• DMSO(mg / mL) Max Solubility: 84
• DMSO(mM) Max Solubility: 199.83822619784
• Water(mg / mL) Max Solubility: ＜1