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· · COA & SDS available for every product · Same-day shipping on in-stock items BIBX 1382 dihydrochloride - ≥97%(HPLC) , CAS No.1216920-18-1
Synonyms
EC-000.2387 | N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride | Tox21_111996_1 | N8-(3-chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride |
Storage
Store at 2-8°C,Desiccated
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Why this grade ≥97%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
EC-000.2387 | N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5, 4-d]pyrimidine-2, 8-diamine dihydrochloride | Tox21_111996_1 | N8-(3-chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5, 4-d]pyrimidine-2, 8-diamine dihydrochloride |
Specifications & Purity
≥97%(HPLC)
Biochemical and Physiological Mechanisms
Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50= 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50= 3.4μM) and a range of other related tyrosine kinases (IC50> 10μM). Oral administration inhibits gr
Storage
Store at 2-8°C, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles CN1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl.Cl.Cl IUPAC Name 4-N-(3-chloro-4-fluorophenyl)-6-N-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-4,6-diamine;dihydrochloride InChIKey RFXGEKWBTCMDAW-UHFFFAOYSA-N INCHI 1S/C18H19ClFN7.2ClH/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12;;/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24);2*1H Isomeric SMILES CN1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl.Cl.Cl PubChem CID 46861540 Molecular Weight 460.77
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Benzene and substituted derivatives Subclass Aniline and substituted anilines Intermediate Tree Nodes Not available Direct Parent Aniline and substituted anilines Alternative Parents Secondary alkylarylamines Aminopyrimidines and derivatives Chlorobenzenes Fluorobenzenes Piperidines Aryl chlorides Aryl fluorides Imidolactams Heteroaromatic compounds Trialkylamines Azacyclic compounds Hydrocarbon derivatives Hydrochlorides Organochlorides Organofluorides Organopnictogen compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents Aniline or substituted anilines - Aminopyrimidine - Chlorobenzene - Fluorobenzene - Halobenzene - Secondary aliphatic/aromatic amine - Aryl chloride - Aryl fluoride - Aryl halide - Piperidine - Pyrimidine - Imidolactam - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Azacycle - Secondary amine - Organoheterocyclic compound - Organic nitrogen compound - Amine - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organopnictogen compound - Hydrochloride - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as aniline and substituted anilines. These are organic compounds containing an aminobenzene moiety. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 19.39, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 19.39, Max Conc. mM: 50 Molecular Weight 460.800 g/mol XLogP3 Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 4 Exact Mass 459.091 Da Monoisotopic Mass 459.091 Da Topological Polar Surface Area 78.900 Ų Heavy Atom Count 29 Formal Charge 0 Complexity 479.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 3
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