GRADE & PURITY 10mM in DMSO

Synonyms

RG 83606 HCl | (2S,​3S)​- 3-​(acetyloxy)​-​5-​[2-​(dimethylamino)​ethyl]​-​2,​3-​dihydro-​2-​(4-​methoxyphenyl)​-1,​5-​benzothiazepin-​4(5H)​-​one,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Diltiazem HCl Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
In vitro

In vivo

Cell Data

cell lines：HCT116, HCT116 p53−/−, EW36, BL2, NTera2D, NTera2D-DNp53, ARN8, NHDF, SKNH-pCMV and SKNSH-DNp53.

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

RG 83606 HCl | (2S, ​3S)​- 3-​(acetyloxy)​-​5-​[2-​(dimethylamino)​ethyl]​-​2, ​3-​dihydro-​2-​(4-​methoxyphenyl)​-1, ​5-​benzothiazepin-​4(5H)​-​one, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
• WGK Germany: 3
• RTECS: DL0310000
• Alternate CAS: 42399-41-7
• Molecular Weight: 450.98
• Reaxy-Rn: 6889420
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6889420&ln=

Chemical and Physical Properties

• Specific Rotation[α]: 114 to 122 deg(C=1, H2O)
• Melt Point(°C): 210 °C

References

1. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng.  (2022)  Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo.  Frontiers in Pharmacology,      [PMID:36052128] [10.3389/fphar.2022.909168]