Fluticasone propionate-d5 - ≥92%,≥95atom%D , CAS No.1093258-28-6

CAS: 1093258-28-6 Cat. No.: F336070 Molecular Weight: 505.61

GRADE & PURITY ≥92%,≥95 atom% D

Synonyms

[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] 2,2,3,3,3-pentadeuteriopropanoate | DTXSID501101416 | SS-4490 | AKOS025311

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Fluticasone propionate-d5 is the labeled form of fluticasone propionate . Fluticasone propionate is a high affinity, selective glucocorticoid receptor (GR) agonist (K|d|= 0.5 nM). Fluticasone propionate potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC|50|= 3.7 nM)|in vitro|. Fluticasone propionate is a lipophilic anti-inflammatory agent derived from flumethasone .

Specifications

Synonyms

[(6S, 8S, 9R, 10S, 11S, 13S, 14S, 16R, 17R)-6, 9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10, 13, 16-trimethyl-3-oxo-6, 7, 8, 11, 12, 14, 15, 16-octahydrocyclopenta[a]phenanthren-17-yl] 2, 2, 3, 3, 3-pentadeuteriopropanoate | DTXSID501101416 | SS-4490 | AKOS025311

Specifications & Purity

≥92%, ≥95atom%D

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥92%, ≥95 atom% D

Names and Identifiers

• Canonical Smiles: CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
• IUPAC Name: [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] 2,2,3,3,3-pentadeuteriopropanoate
• InChIKey: WMWTYOKRWGGJOA-AMTWIDTLSA-N
• INCHI: 1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1/i1D3,5D2
• Isomeric SMILES: [2H]C([2H])([2H])C([2H])([2H])C(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF
• Alternate CAS: 80474-14-2（unlabelled）
• Molecular Weight: 505.61
• Reaxy-Rn: 30890347
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30890347&ln=

Chemical and Physical Properties

• Solubility: Soluble in chloroform, ethyl acetate, and dichloromethane(Sparingly).
• Refractive Index: n20D1.56 (Predicted)
• Boil Point(°C): 568.3° C
• Melt Point(°C): 265-267° C (dec.)