GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Ginkgo (Ginkgo biloba) Plant Profile: bioactives, mechanism of action, references
Specifications
Synonyms
Ginkgolide B | 15291-77-7 | Ginkolide B | Gingko lactone | BN 52021 | SR-01000597598 | bn52021 | Ginklide B | 7-Deoxyginkgolide C | C20H24O10 | CHEMBL266625 | SCHEMBL14279903 | 1-Hydroxy-(1beta)-Ginkgolide A | BCP25992 | NSC110257 | PDSP1_000734 | PDSP2_000724 | AKOS015895882 | NSC-110257 | t
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Primary constituent of Ginkgo biloba. Potential anticancer agent and neuroprotective.Platelet -activating factor (PAF) antagonist (K i = 1.3 μM). A biologically active terpenic lactone. Anti-inflammatory and neuroprotective effects in vivo. Inhibits ather
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ANTAGONIST, CHANNEL BLOCKER
Mechanism of action
Channel blocker of 5-HT 3A;Channel blocker of 5-HT 3AB;Channel blocker of glycine receptor α1 subunit;Channel blocker of glycine receptor α2 subunit;Channel blocker of glycine receptor α3 subunit;Channel blocker of glycine receptor β subunit;Antagonist of
This compound belongs to the class of organic compounds known as ginkgolides and bilobalides. These are diterpene lactones with a structure based either on the gingkolide or the bilobalide skeleton. The ginkgolide skeleton is a very rigid structure consisting of hexacyclic C20 trilactone. The cis-fused F/A/D/C ring junction forms an empty semi-ball hole, the D ring contains a cage form tetrahydrofuran ring which occupies the center of the empty hole, and the oxygen atoms of the D,C and F ring and 10-hydroxyl group consist of an analogous crown ether structure.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Damu Lin, Hongqiang Wu, Zongwei Zhou, Zhenyu Tao, Tanghong Jia, Weiyang Gao. (2019) Ginkgolide B improves multiterritory perforator flap survival by inhibiting endoplasmic reticulum stress and oxidative stress. JOURNAL OF INVESTIGATIVE SURGERY, [PMID:31870195][10.1080/08941939.2019.1676483]
2.Lingling Wang, Xiuhua Zhao, Fengjian Yang, Weiwei Wu, Yanjie Liu, Li Wang, Lu Wang, Zijian Wang. (2019) Enhanced bioaccessibility in vitro and bioavailability of Ginkgo biloba extract nanoparticles prepared by liquid anti-solvent precipitation. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 54 (6):(2266-2276). [PMID:][10.1111/ijfs.14141]
3.Lingling Wang, Xiuhua Zhao, Yuangang Zu, Weiwei Wu, Yuanyuan Li, Chang Zu, Yin Zhang. (2016) Enhanced dissolution rate and oral bioavailability of ginkgo biloba extract by preparing nanoparticles via emulsion solvent evaporation combined with freeze drying (ESE-FR). RSC Advances, 6 (81):(77346-77357). [PMID:][10.1039/C6RA14771B]
4.Yuan Gang Zu, Lingling Wang, Xiuhua Zhao, Yuanyuan Li, Weiwei Wu, Chang Zu, Yannian Huang, Mingfang Wu, Ziqi Feng. (2016) Purification of Ginkgo biloba Extract by Antisolvent Recrystallization. CHEMICAL ENGINEERING & TECHNOLOGY, 39 (7):(1301-1308). [PMID:][10.1002/ceat.201500691]
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