Hexamethonium Chloride hydrate - ≥99% , CAS No.60-25-3(anhy)

CAS: 60-25-3(anhy) Cat. No.: H157034 Molecular Weight: 273.29(anhy)

GRADE & PURITY ≥99%

Synonyms

Hexamethylenebis(trimethylammonium Chloride) hydrate | N,N,N,N',N',N'-Hexamethyl-1,6-hexanediammonium Dichloride hydrate | Hexane-1,6-bis(trimethylammonium Chloride) hydrate

Storage

Argon charged,Room temperature

Shipped In

Normal

Overview

Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction. 

Application：

Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.

Specifications

Synonyms

Hexamethylenebis(trimethylammonium Chloride) hydrate | N, N, N, N', N', N'-Hexamethyl-1, 6-hexanediammonium Dichloride hydrate | Hexane-1, 6-bis(trimethylammonium Chloride) hydrate

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognit

Storage

Argon charged, Room temperature

Shipped In

Normal

Purity

≥99%

Names and Identifiers

• Alternate CAS: 16986-49-5
• Molecular Weight: 273.29(anhy)

Chemical and Physical Properties

• Solubility: Soluble in water; Soluble in Ethanol; Insoluble in Ether,Chloroform
• Sensitivity: Hygroscopic