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CRM1

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  1. Leptomycin B
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    Leptomycin B
    CAS: 87081-35-4 Formula: C33H48O6 Molecular Weight: 540.73
    ≥98%
    In Stock Item #: L102387
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    Technical Identifiers
    IUPAC Name
    (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,show more
    SMILES
    CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
    InChIKey
    YACHGFWEQXFSBS-XYERBDPFSA-N
    InChI
    1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-2show more
    Synonyms
    2,10,12,16,18-Nonadecapentaenoic acid, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7...
  2. KPT-185
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    KPT-185
    CAS: 1333151-73-7 Formula: C16H16F3N3O3 Molecular Weight: 355.31
    ≥98%
    In Stock Item #: K129656
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    Technical Identifiers
    IUPAC Name
    propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate
    SMILES
    CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
    InChIKey
    NLNGWFLRRRYNIL-PLNGDYQASA-N
    InChI
    1S/C16H16F3N3O3/c1-10(2)25-14(23)4-5-22-9-20-15(21-22)11-6-12(16(17,18)19)8-13(7-11)24-3/h4-10H,1-3H3/b5-4-
    Synonyms
    KPT185 | KPT 185 | (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic Acid 1-Methylet...
  3. KPT-276
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    KPT-276
    CAS: 1421919-75-6 Formula: C16H10F8N4O Molecular Weight: 426.26
    ≥98%
    In Stock Item #: K129659
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    Technical Identifiers
    IUPAC Name
    (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
    SMILES
    C1C(CN1C(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)(F)F
    InChIKey
    JCHAWRDHMUSLMM-UPHRSURJSA-N
    InChI
    1S/C16H10F8N4O/c17-14(18)6-27(7-14)12(29)1-2-28-8-25-13(26-28)9-3-10(15(19,20)21)5-11(4-9)16(22,23)24/h1-5,8H,6-7H2/b2-1-
    Synonyms
    2-Propen-1-one, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-, (2Z)- | ...
  4. Eltanexor (KPT-8602), Inhibitor of exportin 1
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    Eltanexor (KPT-8602), Inhibitor of exportin 1
    CAS: 1642300-52-4 Formula: C17H10F6N6O Molecular Weight: 428.29
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: E422031
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    Technical Identifiers
    IUPAC Name
    (E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-2-pyrimidin-5-ylprop-2-enamide
    SMILES
    C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)C=C(C3=CN=CN=C3)C(=O)N
    InChIKey
    JFBAVWVBLRIWHM-AWNIVKPZSA-N
    InChI
    1S/C17H10F6N6O/c18-16(19,20)11-1-9(2-12(3-11)17(21,22)23)15-27-8-29(28-15)6-13(14(24)30)10-4-25-7-26-5-10/h1-8H,(H2,24,30)/b13-6+
    Synonyms
    5-Pyrimidineacetamide, alpha-((3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)methylene)-, (alphaE)- | (2E)...
  5. Eltanexor (KPT-8602), Inhibitor of exportin 1
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    Eltanexor (KPT-8602), Inhibitor of exportin 1
    CAS: 1642300-52-4 Formula: C17H10F6N6O Molecular Weight: 428.29
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: E414000
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-2-pyrimidin-5-ylprop-2-enamide
    SMILES
    C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)C=C(C3=CN=CN=C3)C(=O)N
    InChIKey
    JFBAVWVBLRIWHM-AWNIVKPZSA-N
    InChI
    1S/C17H10F6N6O/c18-16(19,20)11-1-9(2-12(3-11)17(21,22)23)15-27-8-29(28-15)6-13(14(24)30)10-4-25-7-26-5-10/h1-8H,(H2,24,30)/b13-6+
    Synonyms
    5-Pyrimidineacetamide, alpha-((3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)methylene)-, (alphaE)- | (2E)...
  6. KPT 251
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    KPT 251
    CAS: 1388841-50-6 PubChem CID: 57519758 Formula: C14H7F6N5O Molecular Weight: 375.23
    Out of Stock Item #: K357105
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    Technical Identifiers
    IUPAC Name
    2-[(Z)-2-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]ethenyl]-1,3,4-oxadiazole
    SMILES
    C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)C=CC3=NN=CO3
    InChIKey
    LDFXTRYMMZGKIC-UPHRSURJSA-N
    InChI
    1S/C14H7F6N5O/c15-13(16,17)9-3-8(4-10(5-9)14(18,19)20)12-21-6-25(24-12)2-1-11-23-22-7-26-11/h1-7H/b2-1-
    Synonyms
    CRM1 Inhibitor IV | (Z)-2-(2-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole
  7. KPT 330, Exportin-1 inhibitor
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    KPT 330, Exportin-1 inhibitor
    CAS: 1393477-72-9 EC Number: 811-475-6 Formula: C17H11F6N7O Molecular Weight: 443.31
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: K357106
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide
    SMILES
    C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
    InChIKey
    DEVSOMFAQLZNKR-RJRFIUFISA-N
    InChI
    1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-
    Synonyms
    J-690156 | Selinexor [USAN:INN] | Xpovio | (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyraz...
  8. KPT-185
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    KPT-185
    CAS: 1333151-73-7 Formula: C16H16F3N3O3 Molecular Weight: 355.31
    10mM in DMSO
    In Stock Item #: K421259
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate
    SMILES
    CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
    InChIKey
    NLNGWFLRRRYNIL-PLNGDYQASA-N
    InChI
    1S/C16H16F3N3O3/c1-10(2)25-14(23)4-5-22-9-20-15(21-22)11-6-12(16(17,18)19)8-13(7-11)24-3/h4-10H,1-3H3/b5-4-
    Synonyms
    KPT185; KPT 185;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl...
  9. KPT-276
    Wish List Compare
    KPT-276
    CAS: 1421919-75-6 Formula: C16H10F8N4O Molecular Weight: 426.26
    10mM in DMSO
    In Stock Item #: K421564
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
    SMILES
    C1C(CN1C(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)(F)F
    InChIKey
    JCHAWRDHMUSLMM-UPHRSURJSA-N
    InChI
    1S/C16H10F8N4O/c17-14(18)6-27(7-14)12(29)1-2-28-8-25-13(26-28)9-3-10(15(19,20)21)5-11(4-9)16(22,23)24/h1-5,8H,6-7H2/b2-1-
    Synonyms
    2-Propen-1-one, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-, (2Z)-;(Z...
  10. Verdinexor
    Wish List Compare
    Verdinexor
    CAS: 1392136-43-4 PubChem CID: 71492799 Formula: C18H12F6N6O Molecular Weight: 442.32
    10mM in DMSO
    In Stock Item #: V421474
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide
    SMILES
    C1=CC=NC(=C1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
    InChIKey
    OPAKEJZFFCECPN-XQRVVYSFSA-N
    InChI
    1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4-
    Synonyms
    2-Propenoic acid, 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-pyridinyl)hydrazide, (2Z)- | KP...
  11. Verdinexor - ≥98% CAS No(1392136-43-4) by Aladdin Scientific
    Wish List Compare
    Verdinexor
    CAS: 1392136-43-4 PubChem CID: 71492799 Formula: C18H12F6N6O Molecular Weight: 442.32
    ≥98%
    In Stock Item #: V347080
    View Product
    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide
    SMILES
    C1=CC=NC(=C1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
    InChIKey
    OPAKEJZFFCECPN-XQRVVYSFSA-N
    InChI
    1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4-
    Synonyms
    2-Propenoic acid, 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-pyridinyl)hydrazide, (2Z)- | KP...
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