LPA2 antagonist 2 - ≥95% , CAS No.36840-10-5

CAS: 36840-10-5 Cat. No.: L650214 Molecular Weight: 380.35

GRADE & PURITY ≥95%

Synonyms

4,4'-(4,4'-Biphenyldiyldiimino)bis(4-oxo-2-butenoic acid) | E,E-3-[4'-(3-Carboxy-acryloylamino)-biphenyl-4-ylcarbamoyl]-acrylic acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

LPA2 antagonist 2 (H2L 5226501) is a selective LPA 2 antagonist with an IC 50 of 28.3 nM and a K i of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA 3 ( IC 50 of 13.85 μM)

In Vitro

Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA 1 with an Imax of 59.0% at 30 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 28.3 nM (LPA 2 ),13.85 μM (LPA 3 )

Specifications

Synonyms

4, 4'-(4, 4'-Biphenyldiyldiimino)bis(4-oxo-2-butenoic acid) | E, E-3-[4'-(3-Carboxy-acryloylamino)-biphenyl-4-ylcarbamoyl]-acrylic acid

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

LPA2 antagonist 2 (H2L 5226501) is a selective LPA 2 antagonist with an IC 50 of 28.3 nM and a K i of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA 3 ( IC 50 of 13.85 μM).

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥95%

Names and Identifiers

• Molecular Weight: 380.35

Chemical and Physical Properties

• Solubility: DMSO : 83.33 mg/mL (219.09 mM; Need ultrasonic)