meso-2,3-Dimercaptosuccinic acid - 10mM in DMSO , Lead chelating agent, CAS No.304-55-2, Lead chelating agent

CAS: 304-55-2 Cat. No.: M423151 Molecular Weight: 182.22 Beilstein Registry Number: 1725150 EC Number: 206-155-2
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Synonyms
DIM-SA | DMS | DMSA | DMSA (Meso-2,3-dimercaptosuccinic acid) | HSDB 6783 | meso-Dimercaptosuccinic acid | Acid, meso-Dimercaptosuccinic | Butanedioic acid, 2,3-dimercapto-, (R*,S*)- | Succimero [INN-Spanish] | SUCCIMER [USAN] | D00572 | meso-2,3-Dimercap
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
M423151-1ml
1
$17.90
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents.
A water-soluble chelating agent.

Specifications

Synonyms
DIM-SA | DMS | DMSA | DMSA (Meso-2, 3-dimercaptosuccinic acid) | HSDB 6783 | meso-Dimercaptosuccinic acid | Acid, meso-Dimercaptosuccinic | Butanedioic acid, 2, 3-dimercapto-, (R*, S*)- | Succimero [INN-Spanish] | SUCCIMER [USAN] | D00572 | meso-2, 3-Dimercap
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Lead chelating agent and ROS° scavenger. Hypotensive effect in vitro . Reduces oxidative stress and apoptosis in vivo . Orally active. Active in vivo and in vitro .
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
CHELATING AGENT
Mechanism of action
Lead chelating agent
Product Properties
ALogP0.1
Names and Identifiers
Canonical SmilesC(C(C(=O)O)S)(C(=O)O)S
IUPAC Name(2S,3R)-2,3-bis(sulfanyl)butanedioic acid
InChIKeyACTRVOBWPAIOHC-XIXRPRMCSA-N
INCHI1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
Isomeric SMILES [C@@H]([C@@H](C(=O)O)S)(C(=O)O)S
WGK Germany 2
RTECS WM7650000
Molecular Weight 182.22
Beilstein 1725150
Reaxy-Rn 1725149
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1725149&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassLipids and lipid-like molecules
ClassFatty Acyls
SubclassFatty acids and conjugates
Intermediate Tree Nodes Not available
Direct ParentThia fatty acids
Alternative Parents Dicarboxylic acids and derivatives  alpha-Mercaptocarboxylic acids  Alkylthiols  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic acyclic compounds
Substituents Thia fatty acid - Dicarboxylic acid or derivatives - 2-mercaptocarboxylic acid - Carboxylic acid - Carboxylic acid derivative - Alkylthiol - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as thia fatty acids. These are fatty acid derivatives obtained by insertion of a sulfur atom at specific positions in the chain.
External Descriptors dicarboxylic acid - dithiol - sulfur-containing carboxylic acid
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
groL GroEL/GroES (1042 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Sensitivityair sensitive
Melt Point(°C)196-198°C
Molecular Weight182.200 g/mol
XLogP30.100
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass181.971 Da
Monoisotopic Mass181.971 Da
Topological Polar Surface Area76.600 Ų
Heavy Atom Count10
Formal Charge0
Complexity139.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao.  (2023)  A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples.  NEW JOURNAL OF CHEMISTRY,  47  (16): (7862-7872).  [PMID:] [10.1039/D3NJ00488K]
2. Yanjun Huang, Qingdi Kong, Xiaojie Zhang, Hong Peng.  (2022)  DMSA-incorporated silsesquioxane-based hybrid polymer for selective adsorption of Pb(II) from wastewater.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.120723]
3. Min Chen, Jun Wang, Qianbo Zhang, Jinsheng Zhang, Zhiming Chen, Rongguo Sun.  (2022)  Reversible detection of Hg(II) in pure water based on thymine modified nitrogen, sulfur co-doped carbon dots combined with antidote.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36279800] [10.1016/j.saa.2022.121998]
4. Zhongyuan Chen, Yueting Peng, Yichao Li, Xiaoxue Xie, Xiaodan Wei, Geng Yang, Hanxi Zhang, Ningxi Li, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Fengming You, Hong Yang, Yiyao Liu.  (2021)  Aptamer-Dendrimer Functionalized Magnetic Nano-Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy.  ACS Nano,      [PMID:34586789] [10.1021/acsnano.1c06667]
5. Fan Lu, Yeling Yang, Yucheng Liu, Fubing Wang, Xinghu Ji, Zhike He.  (2020)  Point-of-care testing (POCT) of patients with a high concentration of uric acid by using alginate hydrogel microspheres embedded with CdZnTeS QDs and urate oxidase (Alg@QDs-UOx MSs).  ANALYST,  146  (3): (949-955).  [PMID:33245089] [10.1039/D0AN02029J]
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7. Guobin Mao, Wenquan Peng, Songbai Tian, Jiao Zheng, Xinghu Ji, Zhike He.  (2018)  Dual-protein visual detection using ratiometric fluorescent probe based on Rox-DNA functionalized CdZnTeS QDs.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2018.12.065]
8. Xueyi Guo, Weijia Wang, Xiuhong Yuan, Ying Yang, Qinghua Tian, Yang Xiang, Yan Sun, Zhiming Bai.  (2018)  Heavy metal redistribution mechanism assisted magnetic separation for highly-efficient removal of lead and cadmium from human blood.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:30390582] [10.1016/j.jcis.2018.10.095]
9. Yingxin Ma, Guobin Mao, Yucheng Zhong, Guoqiang Wu, Wanjun Wu, Yonghao Zhan, Zhike He, Weiren Huang.  (2018)  Highly sensitive ratiometric fluorescent paper sensor for the urine assay of cancer.  TALANTA,      [PMID:30609522] [10.1016/j.talanta.2018.10.045]
10. Guobin Mao, Mingyuan Du, Xinxin Wang, Xinghu Ji, Zhike He.  (2018)  Simple construction of ratiometric fluorescent probe for the detection of dopamine and tyrosinase by the naked eye.  ANALYST,  143  (21): (5295-5301).  [PMID:30283922] [10.1039/C8AN01640B]
11. Zhichao Dai, Hua Ma, Lu Tian, Bo Song, Mingqian Tan, Xiuwen Zheng, Jingli Yuan.  (2018)  Construction of a multifunctional nanoprobe for tumor-targeted time-gated luminescence and magnetic resonance imaging in vitro and in vivo.  Nanoscale,  10  (24): (11597-11603).  [PMID:29892761] [10.1039/C8NR03085E]
12. Guobin Mao, Qin Cai, Fubing Wang, Changliang Luo, Xinghu Ji, Zhike He.  (2017)  One-Step Synthesis of Rox-DNA Functionalized CdZnTeS Quantum Dots for the Visual Detection of Hydrogen Peroxide and Blood Glucose.  ANALYTICAL CHEMISTRY,      [PMID:29019392] [10.1021/acs.analchem.7b03053]
13. Xueyi Guo, Fangfang Mao, Weijia Wang, Ying Yang, Zhiming Bai.  (2015)  Sulfhydryl-Modified Fe3O4@SiO2 Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro.  ACS Applied Materials & Interfaces,      [PMID:26083720] [10.1021/acsami.5b03873]
14. Meng Wei, Xiaobo Wang, Yunhai Mo, Cunqing Kong, Mengqi Zhang, Guanhua Qiu, Zhihong Tang, Jie Chen, Feixiang Wu.  (2024)  Combined Effects of Anti-PD-L1 and Nanosonodynamic Therapy on HCC Immune Activation in Mice: An Investigation.  International Journal of Nanomedicine,      [PMID:39050875] [10.2147/IJN.S427144]
15. Min Li, Wenying Li, Fang Xu, Yiping Pu, Jianguang Li.  (2024)  Global Identification of Anti-Melanoma Cellular Targets by Photochemically Induced Coupling of L-Shikonin Reactions on the Surface of Magnetic Particles.  Pharmaceutics,  16  (12): (1543).  [PMID:39771522] [10.3390/pharmaceutics16121543]
16. Xiaozhou Li, Jie Chen, Bin Wu, Zhen Gao, Bingfang He.  (2024)  Immobilization and Characterization of a Processive Endoglucanase EG5C-1 from Bacillus subtilis on Melamine–Glutaraldehyde Dendrimer-Functionalized Magnetic Nanoparticles.  Nanomaterials,  14  (4): (340).  [PMID:38392713] [10.3390/nano14040340]
17. Lin Yang, Xueling Liu, Bingyue Song, Sixian Yang, Xiaojie Zhang, Chong Zhao, Yixiao Wu, Lei Zhang, Yanjun Huang.  (2025)  Selective adsorption of silver(I) by dimercaptosuccinic acid (DMSA) functionalized polyhedral oligomeric silsesquioxane (POSS)-based hybrid polymer: Behavior and mechanism.  REACTIVE & FUNCTIONAL POLYMERS,      [PMID:] [10.1016/j.reactfunctpolym.2025.106170]
18. Zhongyuan Chen, Yueting Peng, Xiaoxue Xie, Yi Feng, Tingting Li, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu.  (2019)  Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging.  Theranostics,      [PMID:31534519] [10.7150/thno.36545]
19. Han Li, Shuzhen Cheng, Kai Zhou, Jiachen Zang, Zhenyu Wang, Ming Du.  (2025)  Carboxymethyl-β-cyclodextrin grafted chitosan embedded oyster (Crassostrea gigas) ferritin can alleviate lead-induced liver injury by oral administration.  FOOD RESEARCH INTERNATIONAL,      [PMID:40382035] [10.1016/j.foodres.2025.116417]
20. Yuanyuan You, Wanjia Wu, Xiaoting Zheng, Hao Liu, Xiang Zhou, Ningxuan Liu, Jiajia Lu, Sike Lv, Yukang Wen, Ling Lu, Jia Tao, Bingquan Lin, Peng Zhao.  (2025)  The Burst Enhancement of MRI Using Magnetic Resonance Tuning Based Contrast Agents.  ANALYTICAL CHEMISTRY,      [PMID:41108221] [10.1021/acs.analchem.5c02870]
21. Sheng-Ya Guo, Yong Zhang, Xing-Hui Chen, Yi-Wen Zhang, Bing-Bing Cao, Shi-Chang Zhu, Dao-Zong Xia.  (2026)  Protective role and mechanism of flavonoids from Smilax glabra Roxb. against lead-induced neurotoxicity and hematotoxicity in Danio rerio.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:] [10.1016/j.jep.2026.121472]
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