Midodrine hydrochloride - ≥98% , Adrenergic receptor alpha-1 agonist, CAS No.43218-56-0, Adrenergic receptor alpha-1 agonist

CAS: 43218-56-0 Cat. No.: M413320 Molecular Weight: 290.74 EC Number: 256-148-3
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
HMS1922O03 | SR-05000001847-3 | (+/-)-2-AMINO-N-(beta-HYDROXY-2,5-DIMETHOXYPHENETHYL)ACETAMIDE MONOHYDROCHLORIDE | 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride | Hipertan | MIDODRINE HYDROCHLORIDE [MI] | ST 1085 HYDROCHLOR
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
M413320-5mg
2
$28.90
25mg
M413320-25mg
2
$115.90
100mg
M413320-100mg
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$211.90
500mg
M413320-500mg
2
$794.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.

Specifications

Synonyms
HMS1922O03 | SR-05000001847-3 | (+/-)-2-AMINO-N-(beta-HYDROXY-2, 5-DIMETHOXYPHENETHYL)ACETAMIDE MONOHYDROCHLORIDE | 2-Amino-N-(2-(2, 5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride | Hipertan | MIDODRINE HYDROCHLORIDE [MI] | ST 1085 HYDROCHLOR
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
AGONIST
Mechanism of action
Adrenergic receptor alpha-1 agonist
Purity
≥98%
Product Properties
ALogP-0.166
hba_count3
HBD Count3
Rotatable Bond6
Names and Identifiers
Pubchem Sid488182460
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488182460
Canonical SmilesCOC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O.Cl
IUPAC Name2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide;hydrochloride
InChIKeyMGCQZNBCJBRZDT-UHFFFAOYSA-N
INCHI1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
Isomeric SMILES COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O.Cl
Alternate CAS 3092-17-9
Molecular Weight 290.74
Reaxy-Rn 6579688
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6579688&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct ParentAlpha amino acid amides
Alternative Parents Dimethoxybenzenes  Phenoxy compounds  Anisoles  Alkyl aryl ethers  Secondary carboxylic acid amides  Secondary alcohols  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrochlorides  Hydrocarbon derivatives  Carbonyl compounds  Aromatic alcohols  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Alpha-amino acid amide - P-dimethoxybenzene - Dimethoxybenzene - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Carboxamide group - Secondary carboxylic acid amide - Secondary alcohol - Ether - Alcohol - Primary amine - Aromatic alcohol - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Hydrochloride - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Amine - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
External Descriptors hydrochloride
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
B2327957Certificate of AnalysisDec 22, 2025 M413320
B2327950Certificate of AnalysisDec 22, 2025 M413320
B2327505Certificate of AnalysisDec 22, 2025 M413320
B2327504Certificate of AnalysisDec 22, 2025 M413320
B2327503Certificate of AnalysisDec 22, 2025 M413320
B2327498Certificate of AnalysisDec 22, 2025 M413320
B2327448Certificate of AnalysisDec 22, 2025 M413320
B2327432Certificate of AnalysisDec 22, 2025 M413320
C2508149Certificate of AnalysisAug 30, 2022 M413320
Chemical and Physical Properties
SolubilitySolubility (25°C) In vitro DMSO: 58 mg/mL (199.49 mM);    
SensitivityMoisture sensitive
DMSO(mg / mL) Max Solubility58
DMSO(mM) Max Solubility199.490954117081
Water(mg / mL) Max Solubility-1
Molecular Weight290.740 g/mol
XLogP3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass290.103 Da
Monoisotopic Mass290.103 Da
Topological Polar Surface Area93.800 Ų
Heavy Atom Count19
Formal Charge0
Complexity262.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Documents & Articles
Solution Calculators
Reviews

Customer Reviews

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