Oxaliplatin - ≥99% , CAS No.61825-94-3

CAS: 61825-94-3 Cat. No.: O124003 Molecular Weight: 397.29 EC Number: 621-248-1

GRADE & PURITY ≥99%

Synonyms

(trans-1,2-Cyclohexanediamine)oxalatoplatinu | [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum | L-OHP

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.

Application：

Oxaliplatin has been used:as a chemotherapeutic agent in colon rectal adenocarcinoma SW480 cells by cell viability assay；for monitoring cell survival in hepatocellular carcinoma HepG2 and HepG2/R cells by MTT assay；to determine the growth inhibitory effect on human breast adenocarcinoma MDA-MB-231 cells.

Product class
hAPIs, Metal based hAPIs

Chemical properties

Chemical formula

C8H14N2O4Pt

Empirical formula

[Pt((R,R)-dach)(ox)]

Molecular weight

397.28

Metal

Pt

Theoretical metal content

49

Physical state

powder

Color

white

Specifications

Synonyms

(trans-1, 2-Cyclohexanediamine)oxalatoplatinu | [SP-4-2-(1R-trans)]-(1, 2-Cyclohexanediamine-N, N′)[ethanedioata(2--)-O, O’]platinum | L-OHP

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin forms platinum-DNA ad

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488196399
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488196399
• Canonical Smiles: C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]
• InChIKey: ZROHGHOFXNOHSO-BNTLRKBRSA-L
• INCHI: 1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
• Isomeric SMILES: C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]
• WGK Germany: 3
• RTECS: TP2275850
• Molecular Weight: 397.29
• Reaxy-Rn: 14621501

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Cyclohexylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Cyclohexylamines
• Intermediate Tree Nodes: Not available
• Direct Parent: Cyclohexylamines
• Alternative Parents: Dicarboxylic acids and derivatives Organic transition metal salts Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Not available
• Substituents: Cyclohexylamine - Dicarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Organic transition metal salt - Amine - Organic salt - Primary amine - Organooxygen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as cyclohexylamines. These are organic compounds containing a cyclohexylamine moiety, which consist of a cyclohexane ring attached to an amine group.
• External Descriptors: platinum coordination entity

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO：DMSO inactivates the activity of Oxaliplatin；H2O：Sonification and heating to 60℃ are recommended；DMF：Sonification is recommended；
• Sensitivity: Heat Sensitive；Moisture sensitive；Light sensitive
• Molecular Weight: 397.290 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 397.06 Da
• Monoisotopic Mass: 397.06 Da
• Topological Polar Surface Area: 76.600 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 191.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

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