Phenylhydrazine hydrochloride - ≥98% , CAS No.27140-08-5

CAS: 27140-08-5 Cat. No.: P104684 Molecular Weight: 144.6 Beilstein Registry Number: 3594958 EC Number: 248-259-0

GRADE & PURITY ≥98%

Synonyms

CAS-59-88-1 | DTXCID701148 | Phenylhydrazinium chloride | WLN: ZMR &GH | Hydrazine, phenyl-, hydrochloride | PHENYLHYDRAZINE HYDROCHLORIDE | phenyl-hydrazine hydrochloride | Tox21_111618 | J-523952 | JOVOSQBPPZZESK-UHFFFAOYSA-N | NSC5710 | NSC-5710 | Phen

Storage

Protected from light,Argon charged

Shipped In

FedEx DG Service

Overview

Phenylhydrazine hydrochloride is used in the examination of tyrosine phosphorylation of Janus protein tyrosine kinase (JAKs) in the EPO-responsive normal erythroblastoid cells of anemic mice.

Specifications

Synonyms

CAS-59-88-1 | DTXCID701148 | Phenylhydrazinium chloride | WLN: ZMR &GH | Hydrazine, phenyl-, hydrochloride | PHENYLHYDRAZINE HYDROCHLORIDE | phenyl-hydrazine hydrochloride | Tox21_111618 | J-523952 | JOVOSQBPPZZESK-UHFFFAOYSA-N | NSC5710 | NSC-5710 | Phen

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Injecting phenylhydrazine hydrochloride intraperitoneally into wild-type and Hp/Hx single deficient mice can cause acute hemolysis, thereby inhibiting the residual activity of horseradish peroxidase (HRP) in animal tissue slices

Storage

Protected from light, Argon charged

Shipped In

FedEx DG Service

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504753733
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504753733
• Canonical Smiles: C1=CC=C(C=C1)NN.Cl
• IUPAC Name: phenylhydrazine;hydrochloride
• InChIKey: JOVOSQBPPZZESK-UHFFFAOYSA-N
• INCHI: 1S/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H
• Isomeric SMILES: C1=CC=C(C=C1)NN.Cl
• WGK Germany: 3
• RTECS: MV9000000
• Alternate CAS: 59-88-1
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 144.6
• Beilstein: 3594958
• Reaxy-Rn: 3594958
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3594958&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Phenylhydrazines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Phenylhydrazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylhydrazines
• Alternative Parents: Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives Hydrazines and derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Phenylhydrazine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Hydrazine derivative - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylhydrazines. These are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (50 mg/ml), and ethanol. Insoluble in ether.
• Sensitivity: Light,Air & Moisture Sensitive
• Melt Point(°C): 243-246°C
• Molecular Weight: 144.600 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 144.045 Da
• Monoisotopic Mass: 144.045 Da
• Topological Polar Surface Area: 38.100 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 57.500
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Lan Du, Jiang Dai, Zhi-Yuan Xu, Ke-Ke Yang, Yu-Zhong Wang.  (2019)  From shape and color memory PCL network to access high security anti-counterfeit material.  POLYMER,      [PMID:] [10.1016/j.polymer.2019.03.054]

2. Zhou Bohang, Zhang Bingyu, Li Xingqiang, Liu Xiuxiu, Li Hui, Li Ding, Cui Zhiming, Geng Huiling, Zhou Le.  (2018)  New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship.  Scientific Reports,  8  (1): (1-18).  [PMID:29367595] [10.1038/s41598-018-19999-3]

3. Zheng Jiang, Hong Wang, Miao Yu, Cheng Qu, Wei Yue, Qinan Wu.  (2023)  A low-cost efficient online derivatization system for the determination of saccharides by high-performance liquid chromatograph-ultraviolet detector.  JOURNAL OF SEPARATION SCIENCE,  46  (20): (2300384).  [PMID:37691057] [10.1002/jssc.202300384]

4. Qianqian Qi, Zhanyu Zhang, Dun Wang.  (2025)  GSH-responsive paclitaxel prodrug used in chemotherapy in combination with photodynamic therapy.  BIOORGANIC CHEMISTRY,      [PMID:40007348] [10.1016/j.bioorg.2025.108289]