GRADE & PURITYAnimal Free?Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material.Carrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Bioactive?Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure.ActiBioPure™?ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required.His Tag?His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein.≥95%(SDS-PAGE)
Expression System
HEK293
Accession #
P11464-1
Protein Tag
C-His
Expression system
HEK293
Endotoxin Concentration
<0.1 EU/μg
Bioactivity
Measured by its binding ability in a functional ELISA. When Recombinant Human SLITRK5 is coated at 500 ng/mL, Recombinant Human PSG1 binds with an ED50 = 50-300 ng/mL.
Animal Free,Carrier Free,Bioactive,ActiBioPure™,His-Tag,≥95%(SDS-PAGE) ActiBioPure™,Animal Free,Bioactive,Carrier Free,His Tag for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Pregnancy-specific beta-1-glycoprotein 1 (PSG1), also called SP1, PSG1 or B1G1 and designated CD66f, is a secreted glycoprotein of the human PSG family within the CEA (carcinoembryonic antigen) superfamily. PSG1 shares 84-91% amino acid (aa) sequence identity with the most similar family members, PSG3, 4, 6, 7, and 8. Mature PSG1 contains a V-type Ig-like domain that is important for adhesion (N1), and three C2-type Ig-like domains (A1, A2 and B2). Three potential isoforms vary at the extreme C-terminus. Although rodents express pregnancy-specific glycoproteins, identity with human PSG proteins is low and limited to the N1 domain. PSG1 is one of the most abundant fetal proteins found in maternal blood during pregnancy. It is secreted by syncytiotrophoblasts and exerts proangiogenic effect by inducing VEGF-A secretion and formation of tubes in endothelial cells. PSG1 also serves an immunomodulatory function through up-regulation of TGF-beta in macrophages, monocytes, and trophoblasts. In addition PSG1 has been shown to induce secretion of anti-inflammatory cytokines IL-10 and IL-6 in human monocytes. PSG1 binds Integrin alpha IIb beta 3 and inhibits platelet-fibrinogen interactions. Recent studies also suggest PSG1's involvement in cancer biology and correlation with chemotherapy resistance in breast cancer.
Specifications
Product Name
Recombinant Human PSG1 Protein
Synonyms
CD66 antigen-like family member F | Fetal liver non-specific cross-reactive antigen 1/2 | FL-NCA-1/2 | Pregnancy-specific beta-1 glycoprotein C/D | Pregnancy-specific glycoprotein 1 | PS-beta-C/D | PS-beta-G-1 | PSBG-1 | PSG95 | CD66 antigen-like family m
Grade
ActiBioPure™, Animal Free, Bioactive, Carrier Free, His Tag
Measured by its binding ability in a functional ELISA. When Recombinant Human SLITRK5 is coated at 500 ng/mL, Recombinant Human PSG1 binds with an ED50 = 50-300 ng/mL.
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant Human PSG1 Protein (rp150623) - SDS-PAGE 2 μg/lane of Recombinant Human PSG1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 58 - 72 kDa under reducing condition and 53 - 68 kDa under non-reducing condition.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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