Rp-8-Br-cGMPS - Moligand™, ≥98% , CAS No.150418-07-8

CAS: 150418-07-8 Cat. No.: R275791 Molecular Weight: 440.17 PubChem CID: 3035839

GRADE & PURITY Moligand™, ≥98%

Synonyms

DTXSID20933942 | Rp-8-BrcGMPS | (R)-8-Bromoguanosine cyclic 3',5'-(hydrogen phosphorothioate) | O-{[5-(8-Bromo-2-imino-1,2-dihydro-9H-purin-9-yl)-3,4-dihydroxy-2,5-dihydrofuran-2-yl]methyl} dihydrogen phosphorothioate | Rp-8-bromoguanosine 3',5'-cyclic mo

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Synonyms

DTXSID20933942 | Rp-8-BrcGMPS | (R)-8-Bromoguanosine cyclic 3', 5'-(hydrogen phosphorothioate) | O-{[5-(8-Bromo-2-imino-1, 2-dihydro-9H-purin-9-yl)-3, 4-dihydroxy-2, 5-dihydrofuran-2-yl]methyl} dihydrogen phosphorothioate | Rp-8-bromoguanosine 3', 5'-cyclic mo

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

cGMP blocker. Competitively inhibits relaxation elicited by 8-Br-cGMP in isolated rabbit aorta contracted by phenylephrine at 30 μM.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1=C2C(=NC(=N1)N)N(C(=N2)Br)C3C(=C(C(O3)COP(=S)(O)O)O)O
• IUPAC Name: (2R,5R)-2-(2-amino-8-bromopurin-9-yl)-5-(dihydroxyphosphinothioyloxymethyl)-2,5-dihydrofuran-3,4-diol
• InChIKey: NKBRWLDMUXONRI-SPGJFGJESA-N
• INCHI: 1S/C10H11BrN5O6PS/c11-9-14-3-1-13-10(12)15-7(3)16(9)8-6(18)5(17)4(22-8)2-21-23(19,20)24/h1,4,8,17-18H,2H2,(H2,12,13,15)(H2,19,20,24)/t4-,8-/m1/s1
• Isomeric SMILES: C1=C2C(=NC(=N1)N)N(C(=N2)Br)[C@H]3C(=C([C@H](O3)COP(=S)(O)O)O)O
• PubChem CID: 3035839
• Molecular Weight: 440.17

Chemical and Physical Properties

• Solubility: Soluble in water to 50 mM