Sodium Heparan Sulfate - ≥98%, Potency:

CAS: 57459-72-0 Cat. No.: H758197

GRADE & PURITY ≥98%, Potency:<20 IU/mg

Synonyms

HS

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Heparan Sulfate (HS) is a class of sulfated GAGs composed of disaccharide units (GlcUA/IdoUA β/α 1-4GlcNAc) composed of glucuronic acid (GlcUA)/iduronic acid (IdoUA) and N-acetylglucosamine (GlcNAc), which are repeatedly linked by α -1,4-glycosidic bonds. In biosynthesis, HS covalently binds to core proteins to form proteoglycans (HSPGs), which are widely expressed on the cell surface and extracellular matrix; GlcUA can undergo differential isomerization to form IdoUA, and under the action of various sulfate transferases, the N, C6, and C3 positions of GlcNAc and the C2 position of GlcUA in the HS chain are sulfated to form highly complex HS side chains. Compared with heparin (Hep), HS has a more complex structure, manifested by more diverse sulfurization modes, lower IdoA content, and longer polysaccharide chains. The HS polysaccharide chain can be roughly divided into three parts: the NA region, which is the region without sulfation modification; In the NS region, the GlcNAc residues in the disaccharide units have undergone deacetylation and sulfation modifications; The NA/NS region is a mixed region of NA and NS, where many sulfation and isomerization modifications in HS occur. HS participates in various physiological and pathological processes such as growth, development, and disease occurrence through interactions with growth factors, cytokines, matrix proteins, etc.

Specifications

Synonyms

HS

Specifications & Purity

≥98%, Potency:<20 IU/mg

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• WGK Germany: 3
• Alternate CAS: 9050-30-0

Chemical and Physical Properties

• Sensitivity: Light sensitive；Moisture sensitive

References

1. Jiahua Duan, Gaofei Qian, Huikang Zhang, Feifan Wang, Qiang Tian, Dong Lei, Jianning Zhao.  (2025)  3D-Printed Biomimetic Vascular Scaffold Crosslinked with Heparan Sulfate for Sustained Release of PDGFB-LG4 Fusion Protein Promotes Bone Regeneration.  Advanced Science,      [PMID:40145866] [10.1002/advs.202414362]

2. Jianjian Ji, Yingcai Xiong, Keyu Tao, Tao Li, Weiying Ou, Yinghui Zhou, Wenyang Zhang, Ruogu Qi, Shouchuan Wang.  (2024)  Resveratrol inhibits respiratory syncytial virus replication by targeting heparan sulfate proteoglycan.  Food & Function,      [PMID:38270052] [10.1039/D3FO05131E]