TC NTR1 17 - ≥98% , CAS No.1146757-96-1

CAS: 1146757-96-1 Cat. No.: T286902 Molecular Weight: 522.98 PubChem CID: 56660273

GRADE & PURITY ≥98%

Synonyms

ML 301 analog | N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Non-peptide Neurotensin Receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.

Specifications

Synonyms

ML 301 analog | N-[[1-(7-Chloro-4-quinolinyl)-5-(2, 6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50<15.6 nM and Emax= 63% of neurotensin response in Ca2+mobilization assay). Exhibits over 50-fold selectivity for NTS1over NTS2and GPR35.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC(C)CC(C(=O)O)NC(=O)C1=NN(C(=C1)C2=C(C=CC=C2OC)OC)C3=C4C=CC(=CC4=NC=C3)Cl
• IUPAC Name: 2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]-4-methylpentanoic acid
• InChIKey: ZQUSYVORYNBGLG-UHFFFAOYSA-N
• INCHI: 1S/C27H27ClN4O5/c1-15(2)12-20(27(34)35)30-26(33)19-14-22(25-23(36-3)6-5-7-24(25)37-4)32(31-19)21-10-11-29-18-13-16(28)8-9-17(18)21/h5-11,13-15,20H,12H2,1-4H3,(H,30,33)(H,34,35)
• Isomeric SMILES: CC(C)CC(C(=O)O)NC(=O)C1=NN(C(=C1)C2=C(C=CC=C2OC)OC)C3=C4C=CC(=CC4=NC=C3)Cl
• PubChem CID: 56660273
• Molecular Weight: 522.98

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 52.3, Max Conc. mM: 100; Solvent:1eq. NaOH, Max Conc. mg/mL: 26.15, Max Conc. mM: 50
• Sensitivity: Moisture sensitive; Light sensitive; Heat sensitive