Tetrahydrobiopterin - Moligand™, ≥98% , Activator of L-Phenylalanine hydroxylase , CAS No.17528-72-2, Activator of L-Phenylalanine hydroxylase

CAS: 17528-72-2 Cat. No.: T305191 Molecular Weight: 241.25

GRADE & PURITY Moligand™, ≥98%

Synonyms

tetrahydrobiopterin | HY-107383 | 1-(2-amino-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl)propane-1,2-diol | 5-26-18-00418 (Beilstein Handbook Reference) | FT-0700530 | L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon | Q61014518

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.

Specifications

Synonyms

tetrahydrobiopterin | HY-107383 | 1-(2-amino-4-hydroxy-5, 6, 7, 8-tetrahydropteridin-6-yl)propane-1, 2-diol | 5-26-18-00418 (Beilstein Handbook Reference) | FT-0700530 | L-erythro-2-Amino-6-(1, 2-dihydroxypropyl)-5, 6, 7, 8-tetrahydro-4(3H)-pteridinon | Q61014518

Specifications & Purity

Moligand™, ≥98%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of L-Phenylalanine hydroxylase

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O
• IUPAC Name: 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-3H-pteridin-4-one
• InChIKey: FNKQXYHWGSIFBK-UHFFFAOYSA-N
• INCHI: 1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)
• Isomeric SMILES: CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O
• Alternate CAS: 69056-38-8
• Molecular Weight: 241.25

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pteridines and derivatives
      • Subclass Pterins and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pteridines and derivatives
• Subclass: Pterins and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biopterins and derivatives
• Alternative Parents: Secondary alkylarylamines Pyrimidones Aminopyrimidines and derivatives Vinylogous amides Heteroaromatic compounds 1,3-aminoalcohols Secondary alcohols 1,2-diols 1,2-aminoalcohols Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Biopterin - Aminopyrimidine - Pyrimidone - Secondary aliphatic/aromatic amine - Pyrimidine - 1,3-aminoalcohol - Vinylogous amide - Heteroaromatic compound - Secondary alcohol - 1,2-diol - 1,2-aminoalcohol - Secondary amine - Azacycle - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Alcohol - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland.
• External Descriptors: a biopterin

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PAH Tclin Phenylalanine-4-hydroxylase (1 Activities)

Discover Target: PAH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Sensitivity: light sensitive，air sensitive
• Molecular Weight: 241.250 g/mol
• XLogP3: -1.900
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 241.117 Da
• Monoisotopic Mass: 241.117 Da
• Topological Polar Surface Area: 132.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 405.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 3
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Ai Yulin, Huang Yusong, Zhao Hongru, Su Bingmei, Lin Juan.  (2025)  Engineered phenylalanine hydroxylase coupled with an effective cofactor synthesis and regeneration system for high-yield production of 5-hydroxytryptophan.  Bioresources and Bioprocessing,  12  (1): (1-14).  [PMID:40047997] [10.1186/s40643-025-00846-z]