TrkA-IN-4 - ≥99% , CAS No.T658654

CAS: T658654 Cat. No.: T658654 Molecular Weight: 538.47

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a proagent of TrkA-IN-3 ( HY-151948 ). TrkA-IN-4 exhibits potent antinociceptive effects.

Appearance:Solid

IC50& Target:TrkA

In Vitro:TrkA-IN-4 (compound 39) demonstrates 65.1% and 46.3% of kinase inhibition towards TrkA at concentrations of 1 μM and 0.1 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo:TrkA-IN-4 (compound 39) (0.9375-120mg/kg; i.g.) exhibits stronger maximum antinociceptive effects 3 h after administration, with an ED 50 of 7.836mg/kg in hot plate testing on male mice. MCE has not independently confirmed the accuracy of these met

Biological Activity:TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a proagent of TrkA-IN-3 ( HY-151948 ). TrkA-IN-4 exhibits potent antinociceptive effects.

Specifications

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC(OCOC(C1=CN=C(C(NC(C2=CC=C(C(C3=NN(C=C3)C)=C2)C(F)(F)F)=O)=C1)C4=CC=CC=C4)=O)=O
• Molecular Weight: 538.47

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (92.86 mM; ultrasonic and warming and heat to 60°C)