4-Nitrophenyl Chloroformate - ≥98%(T) , CAS No.7693-46-1

CAS: 7693-46-1 Cat. No.: N159046 Molecular Weight: 201.56 Beilstein Registry Number: 518127 EC Number: 231-706-9
AVAILABLE TO ORDER
GRADE & PURITY ≥98%(T)
Synonyms
SCHEMBL14520259 | AKOS024438096 | (4-nitrophenyl)chloroformate | 4-(nitro)phenyl chloroformate | 4-nitrophenyl chioroformate | L-Histidine, monohydrochloride, monohydrate | 4-nitrophenoxycarbonyl chloride | 4-[2-(dimethylamino)ethyl]phenol;hydrochloride |
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5g
N159046-5g
3
$9.90
25g
N159046-25g
3
$18.90
100g
N159046-100g
1
$49.90
500g
N159046-500g
3
$199.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥98%(T) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 49 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Usually used in the preparation of poly(oxyethylene) modified dextrans,and also used to synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.

Specifications

Synonyms
SCHEMBL14520259 | AKOS024438096 | (4-nitrophenyl)chloroformate | 4-(nitro)phenyl chloroformate | 4-nitrophenyl chioroformate | L-Histidine, monohydrochloride, monohydrate | 4-nitrophenoxycarbonyl chloride | 4-[2-(dimethylamino)ethyl]phenol;hydrochloride |
Specifications & Purity
≥98%(T)
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%(T)
Names and Identifiers
Pubchem Sid504755580
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504755580
Canonical SmilesC1=CC(=CC=C1[N+](=O)[O-])OC(=O)Cl
IUPAC Name(4-nitrophenyl) carbonochloridate
InChIKeyNXLNNXIXOYSCMB-UHFFFAOYSA-N
INCHI1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H
Isomeric SMILES C1=CC(=CC=C1[N+](=O)[O-])OC(=O)Cl
WGK Germany 3
UN Number 2923
Packing Group II
Molecular Weight 201.56
Beilstein 518127
Reaxy-Rn 518127
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=518127&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassNitrobenzenes
Intermediate Tree Nodes Not available
Direct ParentNitrobenzenes
Alternative Parents Phenoxy compounds  Nitroaromatic compounds  Organic carbonic acids and derivatives  Propargyl-type 1,3-dipolar organic compounds  Organic oxoazanium compounds  Organopnictogen compounds  Organonitrogen compounds  Organochlorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Nitrobenzene - Phenoxy compound - Nitroaromatic compound - C-nitro compound - Carbonic acid derivative - Organic nitro compound - Organic oxoazanium - Allyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carbonyl group - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organic oxide - Organohalogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as nitrobenzenes. These are compounds containing a nitrobenzene moiety, which consists of a benzene ring with a carbon bearing a nitro group.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

27 results found

Lot NumberCertificate TypeDateItem
G2502375Certificate of AnalysisJul 08, 2025 N159046
G2502374Certificate of AnalysisJul 08, 2025 N159046
G2502373Certificate of AnalysisJul 08, 2025 N159046
C2624049Certificate of AnalysisJul 08, 2025 N159046
G2502372Certificate of AnalysisJul 08, 2025 N159046
F2604171Certificate of AnalysisJul 08, 2025 N159046
A2507698Certificate of AnalysisJan 15, 2025 N159046
K2421211Certificate of AnalysisNov 27, 2024 N159046
K2414615Certificate of AnalysisNov 19, 2024 N159046
K2414614Certificate of AnalysisNov 19, 2024 N159046
K2414591Certificate of AnalysisNov 19, 2024 N159046
H2406650Certificate of AnalysisAug 10, 2024 N159046
H2406649Certificate of AnalysisAug 10, 2024 N159046
H2406648Certificate of AnalysisAug 10, 2024 N159046
F2414067Certificate of AnalysisJul 14, 2023 N159046
G2307460Certificate of AnalysisJul 14, 2023 N159046
G2307463Certificate of AnalysisJul 14, 2023 N159046
G2307461Certificate of AnalysisJul 14, 2023 N159046
G2307459Certificate of AnalysisJul 14, 2023 N159046
A2330151Certificate of AnalysisFeb 01, 2023 N159046
A2330210Certificate of AnalysisFeb 01, 2023 N159046
A2330178Certificate of AnalysisFeb 01, 2023 N159046
I2227549Certificate of AnalysisOct 10, 2022 N159046
I2227558Certificate of AnalysisOct 10, 2022 N159046
I2227470Certificate of AnalysisOct 10, 2022 N159046
I2227613Certificate of AnalysisOct 10, 2022 N159046
A2214195Certificate of AnalysisFeb 14, 2022 N159046

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Chemical and Physical Properties
SolubilitySoluble in acetone, chloroform, acetone, toluene and benzene.
SensitivityMoisture &heat sensitive
Flash Point(°F)230°F
Flash Point(°C)>110℃
Boil Point(°C)159-162°/19mm
Melt Point(°C)75-82℃
Molecular Weight201.560 g/mol
XLogP32.600
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass200.983 Da
Monoisotopic Mass200.983 Da
Topological Polar Surface Area72.100 Ų
Heavy Atom Count13
Formal Charge0
Complexity207.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
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46. Heng Zhang, Yiping Yang, Shengchao Yang, Yuchang Qin, Xuan Lv, Lin Cui, Wei Jia, Zhiyong Liu.  (2025)  NIR Responsive Polymeric Prodrug Micelles ZnPc@P(PEG-CMA-TKGEM) for Combating Gemcitabine Drug Delivery in Anticancer Chemotherapy.  Materials,  18  (17): (4165).  [PMID:40942591] [10.3390/ma18174165]
47. Kun Zhang, Shunxi Wang, Kai Qu, Yi Zhao, Qian Feng, Wei Wu, Xian Qin.  (2026)  pH triggered hierarchical responsive release of RVT to promote diabetic wound healing.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2026.172650]
48. Xinyue Zhao, Naijie Wei, Ziyang Fang, Yingyan Xie, Xiaowen Yan, Qiuquan Wang.  (2026)  A Targeted Covalently Activated Chemotherapy Strategy Synergistically Enhances Cytotoxicity of Ibrutinib and Selectivity of Doxorubicin to B-cell Lymphoma Cells.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:41615077] [10.1021/acs.jmedchem.5c02215]
49. Chaoying Kong, Chuwen Luo, Fuxin Xue, Yajun Xu, Na Shen, Zhaohui Tang, Xuesi Chen.  (2026)  Ultrasound-Triggered Charge-Reversal Nanoparticles via Golgi-Dependent Iterative Transcytosis for Enhanced Deep Tumor Penetration.  ACS Nano,      [PMID:41619197] [10.1021/acsnano.5c14557]
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