Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 24 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.
An antiinflammatory compound
| ALogP | 1.6 |
|---|
| Pubchem Sid | 488179683 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179683 |
| Canonical Smiles | C(CCCC(=O)O)CCCC(=O)O |
| IUPAC Name | nonanedioic acid |
| InChIKey | BDJRBEYXGGNYIS-UHFFFAOYSA-N |
| INCHI | 1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13) |
| Isomeric SMILES | C(CCCC(=O)O)CCCC(=O)O |
| WGK Germany | 1 |
| RTECS | CM1980000 |
| Molecular Weight | 188.22 |
| Beilstein | 1101094 |
| Reaxy-Rn | 1101094 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1101094&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Fatty Acyls |
| Subclass | Fatty acids and conjugates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Medium-chain fatty acids |
| Alternative Parents | Dicarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Medium-chain fatty acid - Dicarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as medium-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms. |
| External Descriptors | Dicarboxylic acids |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 07, 2026 | A108439 | |
| Certificate of Analysis | Mar 07, 2026 | A108439 | |
| Certificate of Analysis | Nov 25, 2024 | A108439 | |
| Certificate of Analysis | Nov 25, 2024 | A108439 | |
| Certificate of Analysis | Nov 16, 2024 | A108439 | |
| Certificate of Analysis | Nov 16, 2024 | A108439 | |
| Certificate of Analysis | Nov 16, 2024 | A108439 | |
| Certificate of Analysis | Sep 14, 2023 | A108439 | |
| Certificate of Analysis | Sep 14, 2023 | A108439 | |
| Certificate of Analysis | Sep 14, 2023 | A108439 | |
| Certificate of Analysis | Sep 14, 2023 | A108439 | |
| Certificate of Analysis | Sep 14, 2023 | A108439 | |
| Certificate of Analysis | May 06, 2023 | A108439 | |
| Certificate of Analysis | May 06, 2023 | A108439 | |
| Certificate of Analysis | May 06, 2023 | A108439 | |
| Certificate of Analysis | May 06, 2023 | A108439 | |
| Certificate of Analysis | Jul 14, 2022 | A108439 | |
| Certificate of Analysis | Jul 14, 2022 | A108439 | |
| Certificate of Analysis | Jul 14, 2022 | A108439 | |
| Certificate of Analysis | Jul 14, 2022 | A108439 | |
| Certificate of Analysis | Jul 14, 2022 | A108439 | |
| Certificate of Analysis | Jul 14, 2022 | A108439 | |
| Certificate of Analysis | Jul 14, 2022 | A108439 | |
| Certificate of Analysis | Jun 05, 2022 | A108439 | |
| Certificate of Analysis | Jun 05, 2022 | A108439 | |
| Certificate of Analysis | Jun 05, 2022 | A108439 | |
| Certificate of Analysis | Mar 30, 2022 | A108439 | |
| Certificate of Analysis | Jul 03, 2021 | A108439 |
| Solubility | Soluble in water (2.4 mg/ml at 20 °C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol. |
|---|---|
| Sensitivity | Moisture sensitive. |
| Refractive Index | 1.4303 |
| Flash Point(°F) | 410 °F |
| Flash Point(°C) | 210 °C |
| Boil Point(°C) | 286°C |
| Melt Point(°C) | 109-111°C |
| Molecular Weight | 188.220 g/mol |
| XLogP3 | 1.600 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 8 |
| Exact Mass | 188.105 Da |
| Monoisotopic Mass | 188.105 Da |
| Topological Polar Surface Area | 74.600 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 147.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen. (2021) ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomaterialia, [PMID:34879292] [10.1016/j.actbio.2021.11.042] |
| 2. Qi Jing, Jin Feiyang, You Yuchan, Du Yan, Liu Di, Xu Xiaoling, Wang Jun, Zhu Luwen, Chen Minjiang, Shu Gaofeng, Wu Liming, Ji Jiansong, Du Yongzhong. (2021) Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles. Nature Communications, 12 (1): (1-17). [PMID:34362890] [10.1038/s41467-021-24902-2] |
| 3. Jiujiang Ji, Guo Chen, Jun Zhao. (2019) Preparation and characterization of amino/thiol bifunctionalized magnetic nanoadsorbent and its application in rapid removal of Pb (II) from aqueous system. JOURNAL OF HAZARDOUS MATERIALS, [PMID:30684763] [10.1016/j.jhazmat.2019.01.035] |
| 4. Gang-Gang Yang, Hang Zhang, Dong-Yang Zhang, Qian Cao, Jing Yang, Liang-Nian Ji, Zong-Wan Mao. (2018) Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo. BIOMATERIALS, [PMID:30227273] [10.1016/j.biomaterials.2018.08.065] |
| 5. Shuai Zhang, Na Sha, Zhe Zhao. (2016) Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions. JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, [PMID:] [10.1016/j.jeurceramsoc.2016.12.013] |
| 6. Zhijuan Sun, Xiao Wang, Fei Guo, Chunyue Jiang, Qinmin Pan. (2015) Isothermal and nonisothermal crystallization kinetics of bio-sourced nylon 69. CHINESE JOURNAL OF CHEMICAL ENGINEERING, [PMID:] [10.1016/j.cjche.2015.12.021] |
| 7. Hongyan Tan, Min He, Dengke Zhang, Yiyu Zang, Donghua Chen, Junjie Fei. (2024) A rhodamine 110 loaded and molecularly imprinted polymers coated millipore filter membrane-based fluorescent sensor for sensitive and selective caffeic acid detection. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.110588] |
| 8. Wanjing Zhang, Liyan Wang, Yunsheng Chong, Wei Liu, Xin Qian. (2025) Development of biocompatible azelaic acid-based copolyester plasticizers for PVC applications. POLYMER, [PMID:] [10.1016/j.polymer.2025.128322] |
| 9. Tao Liu, Youcai Zhu, Yue Mu, Xindi Feng, Zhen Liu. (2024) Enhanced activity for producing CO2-based polyols enabled by Zn-Co DMC/c-CTA catalytic system. Molecular Catalysis, [PMID:] [10.1016/j.mcat.2024.114693] |
| 10. Danqing Song, Qiqi Xie, Jiaying Zhang, Bing Wang, Yi Liu, Sheng Chen, Liuchun Zheng. (2025) High-Performance Poly(amide-urea) via a Nonisocyanate Route with Simultaneously Improved Strength and Toughness. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.4c10057] |
| 11. Zhengyu Zhou, Bingbing Shi, Chengxin Zhang, Yiyun Wang, Pengfei Tang, Jiajun Feng, Jingjing Fan, Feng Jiang, Yongliang Ding. (2024) High-performance sustainable polyester amide composites with persistent luminescence for multiple anti-counterfeiting. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2024.159007] |
| 12. Ling Chen, Zhou Rudong, Xiang Yanli, Fang Jianbo, Meng Xu, Ren Qiang, Wang Chenyi. (2024) Solvent-free flexible epoxy intumescent fire-retardant coatings. Journal of Coatings Technology and Research, [PMID:] [10.1007/s11998-024-00918-3] |
| 13. Yongliang Ding, Chengxin Zhang, Bingbing Shi, Yiyun Wang, Pengfei Tang, Cheng Liu, Jingjing Fan, Zhongkai Wang, Feng Jiang. (2024) Sustainable ultra-strong polyesteramide elastomers with rapid degradation and high resilience. EUROPEAN POLYMER JOURNAL, [PMID:] [10.1016/j.eurpolymj.2024.112901] |
| 14. Wanjing Zhang, Yuqi Shan, Liyan Wang, Yanming Chen, Liying Guo, Yunsheng Chong, Xin Qian. (2025) Synthesis of 2-Methyl-1,3-Propanediol Modified Azelaic Acid-Octanediol Copolyester Plasticizers and Their Plasticizing Effect on Polyvinyl Chloride. JOURNAL OF APPLIED POLYMER SCIENCE, [PMID:] [10.1002/app.56849] |
| 15. Wanjing Zhang, Liyan Wang, Hong Chen, Liying Guo, Yaoyao Bai, Xin Qian. (2024) Synthesis of azelaic acid copolyester plasticizers and their application in PVC. RSC Advances, 14 (33): (23662-23671). [PMID:39077328] [10.1039/D4RA03174A] |
| 16. Zongpeng Liu, Shaojian Hu, Yuning Zhang, Bencheng Wu, Jianhua Zhu. (2024) Synthesis of complex polyolester as base stock for high-performance lubricant: Optimization, characterization, and evaluation. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2024.125494] |
| 17. Yiquan Wang, Yuxiang Liang, Yiya Li, Wenqi Rui, Jingjian He, Mengya Zhao. (2024) Synthesis, tribological properties and oxidative stability of polyol esters base oils containing pentaerythritol complex esters. TRIBOLOGY INTERNATIONAL, [PMID:] [10.1016/j.triboint.2024.109618] |
| 18. Zhaolin Sun, Yuhua Wei, Shuangyi Ma, Yuchen Xu, Yuna Zhang, Changxian Li, Jinghan Zhang, Feifei Duan, Jianwei Jiao, Xiuying Duan. (2025) Zhuru extracts ameliorate lipid accumulation of MASLD via suppressing the mTORC1/SREBPs pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40617366] [10.1016/j.jep.2025.120246] |
| 19. Wang Guoqiang, Yu Yiheng, Zhang Mengke, Shi Longqing, Hu Hongliang, Jin Yujie, Hu Jing. (2025) 1,4-Cyclohexanedimethanol-based polyesters derived from 1,4-cyclohexanedimethanol (CHDM) and aliphatic diacids with odd carbons. POLYMER BULLETIN, [PMID:] [10.1007/s00289-025-05887-0] |
| 20. Dequan Chi, Chao Wu, Haoyu Gu, Xinchao Sun, Ruoxi Zhao, Dongjie Zhang, Zhimin Xie, Zhongjun Cheng, Yuyan Liu. (2025) Tailored cocrystal architectures enable highly reversible actuation in crystalline polymer networks. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.169166] |
| 21. Jingzhe Sheng, Tengda Du, Jingyi Zhang, Yuetong Huang, Shuo Wang, Mengyu Liu, Tao Zhang, YingJie Zhao, Hao Zhang, Qian Lv, Can Zhao, Xiaoxue He, Xinyu Cui, Mengze Gao, Qi Lu, Zhonggui He, Bingjun Sun, Tian Liu, Jin Sun. (2025) Programmable manganese-chalcogen coordination nanoregulator enables dual-lock prodrug activation through electron cloud engineering for synergistic chemo-metalloimmunotherapy. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.170866] |
| 22. Mingyuan Wei, Xinzhu Yi, Zhuandi Lin, Jingjing Cai, Shanze Chen, Fang Zhou, Hanqin Cai, Xinfeng Lu, Juan Tang, Yunfeng Shi, Liping Cui, Lei Yang, Xinru Jing, Yunong Zeng, Rong Wu, Tingting Shu, Yuanyuan Li, Fangyuan Yang, Yi He, Zhibin Zhao, Yuqiong Yang, Wenjiao Zhu, Qiong Jiang, Weiwei Zhang, Xiang Tan, Zhuo Ma, Xiaoying Fan, Wei Ma, Sheng Li, Wensheng Shu, Hong Wei, Zhiming Xiang, Jack A. Gilbert, Shenhai Gong, Zhang Wang. (2026) Ketogenic diet alleviates septic lung injury via microbial gut-lung axis. Cell Metabolism, [PMID:41643678] [10.1016/j.cmet.2026.01.005] |
| 23. Zhou Xiaorui, Yang Ying, Lv Chang, Cheng Xinru, Hao Wenbo, Su Tingting, Huang Chenhao, Hu Bing. (2026) Influence of Carbon Chain Length and Odd–Even Effect on the Properties of Azelaic Acid-Based Aliphatic Polyesters. JOURNAL OF POLYMERS AND THE ENVIRONMENT, 34 (4): (80). [PMID:] [10.1007/s10924-026-03770-1] |
| 24. Shibo Pei, Yanli Xiang, Peng Zhang, Xv Meng, Chenyi Wang, Qiang Ren. (2026) Reactive and flexible graft polyesters with polydimethylsiloxane side chains as versatile tougheners for epoxies. REACTIVE & FUNCTIONAL POLYMERS, [PMID:] [10.1016/j.reactfunctpolym.2026.106719] |
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