DSPE PEG Amine, DSPE-PEG-NH2 - MW 2000 Da , CAS No.474922-26-4

CAS: 474922-26-4 Cat. No.: D163596 PubChem CID: 156592378

GRADE & PURITY MW 2000 Da

Synonyms

DSPE-PEG-NH2 | DSPE-PEG2000-NH2 | PD070000 | DSPE-PEG-Amine | 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] Ammonium Salt | α-[(9R)-6-Hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanon

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

DSPE PEG Amine (DSPE-PEG-NH2) is one of  reactive phospholipid PEG reagents that have a reactive primary amine group on one PEG terminus. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine) is a saturated 18C phospholipid commonly used in liposome synthesis.  Polyethylene glycol (PEG) conjugated DSPE has both hydrophilicity and hydrophobility property that is useful for drug delivery, gene transfection and biomolecule modification. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. Amine functionalized DSPE PEG allows further modification of PEG lipid via its reactive amino group.

Application：

DSPE-PEG-NH2 is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an amine. DSPE-PEG-NH2 is used to modify liposome surface with biomolecules containing amine reactive groups (NHS, thiolate). It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.

Specifications

Synonyms

DSPE-PEG-NH2 | DSPE-PEG2000-NH2 | PD070000 | DSPE-PEG-Amine | 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] Ammonium Salt | α-[(9R)-6-Hydroxy-6-oxido-1, 12-dioxo-9-[(1-oxooctadecyl)oxy]-5, 7, 11-trioxa-2-aza-6-phosphanon

Specifications & Purity

MW 2000 Da

Biochemical and Physiological Mechanisms

DSPE-PEG(2000) micelles facilitate solubilization and delivery of hydrophobic drugs. It is used to coat magnetic iron oxide nanoparticles

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Pubchem Sid: 504773717
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773717
• Canonical Smiles: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)OCCOCCN)OC(=O)CCCCCCCCCCCCCCCCC.N
• IUPAC Name: [3-[2-[2-(2-aminoethoxy)ethoxycarbonylamino]ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate;azane
• InChIKey: AXHRCGLQEUQOIS-UHFFFAOYSA-N
• INCHI: 1S/C46H91N2O11P.H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-44(49)56-41-43(42-58-60(52,53)57-38-36-48-46(51)55-40-39-54-37-35-47)59-45(50)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h43H,3-42,47H2,1-2H3,(H,48,51)(H,52,53);1H3
• Isomeric SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)OCCOCCN)OC(=O)CCCCCCCCCCCCCCCCC.N
• PubChem CID: 156592378

Chemical and Physical Properties

• Solubility: Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents
• Sensitivity: Heat sensitive；Moisture sensitive

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