Cariprazine - Moligand™, ≥98% , Agonist of D 2 receptor;Agonist of D 3 receptor, CAS No.839712-12-8, Agonist of D 2 receptor;Agonist of D 3 receptor

CAS: 839712-12-8 Cat. No.: C126186 Molecular Weight: 427.41 EC Number: 111-198-4

GRADE & PURITY Moligand™, ≥98%

Synonyms

AS-74411 | AKOS027250814 | 5-chloro-2-mercapto-benzoxazol | DB06016 | FT-0605496 | GLXC-90442 | Q2938837 | BDBM50443094 | DTXSID60220767 | AC-35342 | RGH-188; RGH188; RGH 188; MP-214; MP 214; MP214 | US9550741, RGH-188 | EN300-7406880 | MFCD19443701 | BDB

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Cariprazine(RGH188) is a novel antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors.

Specifications

Synonyms

AS-74411 | AKOS027250814 | 5-chloro-2-mercapto-benzoxazol | DB06016 | FT-0605496 | GLXC-90442 | Q2938837 | BDBM50443094 | DTXSID60220767 | AC-35342 | RGH-188; RGH188; RGH 188; MP-214; MP 214; MP214 | US9550741, RGH-188 | EN300-7406880 | MFCD19443701 | BDB

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Description:
IC50 Value: 0.5 and 0.09 nM (Ki for D2 and D3 receptor respectively); 2.6 and 180 nM(Ki for 5-HT1A and 5-HT2A receptor respectively) [1]
Cariprazine is a novel antipsychotic drug candidate that exhibits high selecti

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of D 2 receptor;Agonist of D 3 receptor

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
• IUPAC Name: 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea
• InChIKey: KPWSJANDNDDRMB-UHFFFAOYSA-N
• INCHI: 1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)
• Isomeric SMILES: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
• Molecular Weight: 427.41
• Reaxy-Rn: 18765165
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18765165&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazinanes
      • Subclass Piperazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazinanes
• Subclass: Piperazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpiperazines
• Alternative Parents: N-arylpiperazines Dichlorobenzenes Dialkylarylamines Aniline and substituted anilines N-alkylpiperazines Aryl chlorides Ureas Trialkylamines Azacyclic compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylpiperazine - N-arylpiperazine - 1,2-dichlorobenzene - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - N-alkylpiperazine - Chlorobenzene - Halobenzene - Aryl chloride - Benzenoid - Aryl halide - Monocyclic benzene moiety - Urea - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organic oxide - Organochloride - Organohalogen compound - Organonitrogen compound - Amine - Organooxygen compound - Carbonyl group - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

DRD2 Tclin D(2) dopamine receptor (24 Activities)

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor (10 Activities)

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: 25°C: DMSO
• Molecular Weight: 427.400 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 426.195 Da
• Monoisotopic Mass: 426.195 Da
• Topological Polar Surface Area: 38.800 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 491.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Haowei Liu, Qiuming Huang, Yunqi Fan, Bo Li, Xuemei Liu, Changhua Hu.  (2023)  Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B.  Acta Pharmaceutica Sinica B,      [PMID:37655314] [10.1016/j.apsb.2023.05.015]

2. Fan Wang, Chao-bao Liu, Yi Wang, Xi-xi Wang, Yuan-yao Yang, Chang-you Jiang, Qiu-min Le, Xing Liu, Lan Ma, Fei-fei Wang.  (2024)  Morphine- and foot shock-responsive neuronal ensembles in the VTA possess different connectivity and biased GPCR signaling pathway.  Theranostics,      [PMID:38250036] [10.7150/thno.90792]

3. Li Hai-bo, Liu Yong-hui, Liu Hai, Li Yuan, Le Qiu-min, Wang Fei-fei, Ma Lan, Liu Xing.  (2026)  G protein-dependent dopamine D2 receptor signaling mediates cocaine-primed reinstatement.  ACTA PHARMACOLOGICA SINICA,      [PMID:41535707] [10.1038/s41401-025-01700-w]